『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=249351EID:249351, Map:0, LastModified:2017年3月7日(火) 10:28:46, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[船木 真理], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.李 勤凱
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[継承]
2. (英) Hosaka Toshio (日) (読)
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[継承]
3.四釜 洋介
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4.坂東 由記子
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5.小杉 知里
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6.片岡 菜奈子
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7.中屋 豊
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8.船木 真理 ([徳島大学.病院.中央診療施設等.糖尿病対策センター])
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題名 (必須): (英) Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Although an inverse correlation between insulin sensitivity and the level of Gq/11-coupled receptor agonists, such as endothelin-1, thrombin, and 5-hydroxytryptamine (5-HT), has been reported, its precise mechanism remains unclear. In this report, we provide evidence that 5-HT induced production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and caused insulin resistance in 3T3-L1 adipocytes, primary adipocytes, and C2C12 myotubes. In 3T3-L1 adipocytes, 5-HT stimulated HB-EGF production by promoting metalloproteinase-dependent shedding of transmembrane protein pro-HB-EGF. HB-EGF then bound and tyrosine-phosphorylated EGF receptors, which activated the mammalian target of rapamycin pathway through ERK1/2 phosphorylation. Mammalian target of rapamycin activation caused serine phosphorylation of insulin receptor substrate-1, which attenuated insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 and glucose uptake. Pharmacological inhibition of either Gq/11-coupled receptors or metalloproteinases, as well as either inhibition or knockdown of HB-EGF or Gq/11, restored insulin signal transduction impaired by 5-HT. Inhibition of metalloproteinase activity also abolished HB-EGF production and subsequent EGF receptor activation by other Gq/11-coupled receptor agonists known to cause insulin resistance, such as endothelin-1 and thrombin. These results suggest that transactivation of the EGF receptor through HB-EGF processing plays a pivotal role in 5-HT-induced insulin resistance.  (日)    [継承]
キーワード (推奨): 1. (英) 3T3-L1 Cells (日) (読) [継承]
2. (英) Adipocytes (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Endothelin-1 (日) (読) [継承]
7. (英) GTP-Binding Protein alpha Subunits, Gq-G11 (日) (読) [継承]
8. (英) Glucose (日) (読) [継承]
9. (英) Insulin (日) (読) [継承]
10. (英) Insulin Receptor Substrate Proteins (日) (読) [継承]
11. (英) Insulin Resistance (日) (読) [継承]
12. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
13. (英) MAP Kinase Signaling System (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Muscle Fibers, Skeletal (日) (読) [継承]
16. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
17. (英) Receptor, Epidermal Growth Factor (日) (読) [継承]
18. (英) Serotonin (日) (読) [継承]
19. (英) Signal Transduction (日) (読) [継承]
20. (英) TOR Serine-Threonine Kinases (日) (読) [継承]
21. (英) Thrombin (日) (読) [継承]
22. (英) Transcriptional Activation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2012年 0月 初日 (平成 24年 0月 初日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2011-1418    (→Scopusで検索) [継承]
PMID (任意): 22028447    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: The Clinical Research Center for Diabetes, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Qinkai Li, Toshio Hosaka, Yosuke Shikama, Yukiko Bandou, Chisato Kosugi, Nanako Kataoka, Yutaka Nakaya and Makoto Funaki : Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway., Endocrinology, Vol.153, No.1, 56-68, 2012.
欧文冊子 ● Qinkai Li, Toshio Hosaka, Yosuke Shikama, Yukiko Bandou, Chisato Kosugi, Nanako Kataoka, Yutaka Nakaya and Makoto Funaki : Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway., Endocrinology, Vol.153, No.1, 56-68, 2012.

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