| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 2. | 河野 崇
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| 3. | 北畑 洋
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| 4. | 大藤 純 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.救急集中治療医学]/[徳島大学.病院.診療科.救急科.救急集中治療科])
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| 5. | 髙橋 章 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])
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| 6. | 高石 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学]/[徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.歯科麻酔科学])
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| 7. | 原田 永勝
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| 8. | (英) Nakagawa Tadahiko (日) (読)
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| 9. | (英) Kinoshita Hiroyuki (日) (読)
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| 10. | (英) Azma Toshiharu (日) (読)
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| 11. | 中屋 豊
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| 12. | 大下 修造
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| ○題名 (必須): | □ | (英) Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels. (日)
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| ○要約 (任意): | □ | (英) We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) COS Cells (日) (読)
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| 3. | (英) Cell Line (日) (読)
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| 4. | (英) Cercopithecus aethiops (日) (読)
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| 5. | (英) Clonidine (日) (読)
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| 6. | (英) Humans (日) (読)
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| 7. | (英) KATP Channels (日) (読)
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| 8. | (英) Muscle, Smooth, Vascular (日) (読)
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| 9. | (英) Potassium Channel Blockers (日) (読)
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| 10. | (英) Potassium Channels, Inwardly Rectifying (日) (読)
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| 11. | (英) Rats (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Anesthesia & Analgesia (International Anesthesia Research Society(IARS))
(pISSN: 0003-2999, eISSN: 1526-7598)
| ○ISSN (任意): | □ | 1526-7598
ISSN: 0003-2999
(pISSN: 0003-2999, eISSN: 1526-7598) Title: Anesthesia and analgesiaTitle(ISO): Anesth AnalgPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 113
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1374 1380
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 10月 14日 (平成 23年 10月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1213/ANE.0b013e3182321142 (→Scopusで検索)
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| ○PMID (任意): | □ | 22003223 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000297375500014
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, Tokushima University Hospital, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. kawahito@pb4.so-net.ne.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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