『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Katoh Akiko (日) (読)
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学籍番号 (推奨):
[継承]
2.藤原 広明
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[継承]
3. (英) Ohbuchi Toyoaki (日) (読)
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[継承]
4. (英) Onaka Tatsushi (日) (読)
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[継承]
5. (英) Hashimoto Takashi (日) (読)
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6. (英) Kawata Mitsuhiro (日) (読)
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7. (英) Suzuki Hideaki (日) (読)
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8. (英) Ueta Yoichi (日) (読)
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[継承]
題名 (必須): (英) Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have generated rats bearing an oxytocin (OXT)-monomeric red fluorescent protein 1 (mRFP1) fusion transgene. The mRFP1 fluorescence was highly visible in ventral part of the supraoptic nucleus (SON) and the posterior pituitary in a whole mount. mRFP1 fluorescence in hypothalamic sections was also observed in the SON, the paraventricular nucleus (PVN), and the internal layer of the median eminence. Salt loading for 5 d caused a marked increase in mRFP1 fluorescence in the SON, the PVN, the median eminence, and the posterior pituitary. In situ hybridization histochemistry revealed that the expression of the mRNA encoding the OXT-mRFP1 fusion gene was observed in the SON and the PVN of euhydrated rats and increased dramatically after chronic salt loading. The expression of the endogenous OXT and the arginine vasopressin (AVP) genes were significantly increased in the SON and the PVN after chronic salt loading in both nontransgenic and transgenic rats. These responses were not different between male and female rats. Compared with nontransgenic rats, euhydrated and salt-loaded male and female transgenic rats showed no significant differences in plasma osmolality, sodium concentration, OXT, and AVP levels. Finally, we succeeded in generating a double-transgenic rat that expresses both the OXT-mRFP1 fusion gene and the AVP-enhanced green fluorescent protein fusion gene. Our new transgenic rats are valuable new tools to study the physiology of the hypothalamo-neurohypophysial system.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arginine Vasopressin (日) (読) [継承]
3. (英) Female (日) (読) [継承]
4.遺伝子発現 (gene expression) [継承]
5. (英) Green Fluorescent Proteins (日) (読) [継承]
6. (英) Hypothalamo-Hypophyseal System (日) (読) [継承]
7. (英) Luminescent Proteins (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Median Eminence (日) (読) [継承]
10. (英) Molecular Imaging (日) (読) [継承]
11. (英) Nerve Tissue Proteins (日) (読) [継承]
12. (英) Neurons (日) (読) [継承]
13. (英) Organ Specificity (日) (読) [継承]
14. (英) Oxytocin (日) (読) [継承]
15. (英) Paraventricular Hypothalamic Nucleus (日) (読) [継承]
16. (英) RNA, Messenger (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Transgenic (日) (読) [継承]
19. (英) Rats, Wistar (日) (読) [継承]
20. (英) Recombinant Fusion Proteins (日) (読) [継承]
21. (英) Sex Characteristics (日) (読) [継承]
22. (英) Sodium Chloride, Dietary (日) (読) [継承]
23. (英) Supraoptic Nucleus (日) (読) [継承]
24. (英) Water-Electrolyte Balance (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 152 [継承]
(必須): 7 [継承]
(必須): 2768 2774 [継承]
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年月日 (必須): 西暦 2011年 5月 3日 (平成 23年 5月 3日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2011-0006    (→Scopusで検索) [継承]
PMID (任意): 21540286    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-79959470540 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akiko Katoh, Hiroaki Fujihara, Toyoaki Ohbuchi, Tatsushi Onaka, Takashi Hashimoto, Mitsuhiro Kawata, Hideaki Suzuki and Yoichi Ueta : Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats., Endocrinology, Vol.152, No.7, 2768-2774, 2011.
欧文冊子 ● Akiko Katoh, Hiroaki Fujihara, Toyoaki Ohbuchi, Tatsushi Onaka, Takashi Hashimoto, Mitsuhiro Kawata, Hideaki Suzuki and Yoichi Ueta : Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats., Endocrinology, Vol.152, No.7, 2768-2774, 2011.

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