『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.藤原 広明
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Sasaki Kazuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Mishiro-Sato Emi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Ohbuchi Toyoaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Dayanithi Govindan (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yamasaki Motoo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Ueta Yoichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Minamino Naoto (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Neuroendocrine regulatory peptide (NERP)-3, derived from the neurosecretory protein VGF (non-aconymic), is a new biologically active peptide identified through peptidomic analysis of the peptides secreted by an endocrine cell line. Using a specific antibody recognizing the C-terminal region of NERP-3, immunoreactive (ir)-NERP-3 was identified in acid extracts of rat brain and gut as a 30-residue NERP-3 with N-terminal pyroglutamylation. Assessed by radioimmunoassay, ir-NERP-3 was more abundant in the brain, including the posterior pituitary (PP), than in the gut. Immunohistochemistry demonstrated that ir-NERP-3 was significantly increased in the suprachiasmatic nucleus, the magnocellular division of the paraventricular nucleus, and the external layer of the median eminence, but not in the supraoptic nucleus, after dehydration. The immunoreactivity was, however, markedly decreased in all of these locations after chronic salt loading. Intracerebroventricular administration of NERP-3 in conscious rats induced Fos expression in a subset of arginine vasopressin (AVP)-containing neurons in the supraoptic nucleus and the magnocellular division of the paraventricular nucleus. On in vitro isolated rat PP preparations, NERP-3 caused a significant AVP release in a dose-related manner, suggesting that NERP-3 in the PP could be an autocrine activator of AVP release. Taken together, the present results suggest that NERP-3 in the hypothalamo-neurohypophyseal system may be involved in the regulation of body fluid balance.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arginine Vasopressin (日) (読) [継承]
3. (brain) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Intestines (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Nerve Tissue Proteins (日) (読) [継承]
8. (英) Neurons (日) (読) [継承]
9. (英) Paraventricular Hypothalamic Nucleus (日) (読) [継承]
10. (英) Peptides (日) (読) [継承]
11.下垂体 (pituitary gland) [継承]
12. (英) Protein Structure, Tertiary (日) (読) [継承]
13.プロテオミクス (proteomics) [継承]
14. (英) Proto-Oncogene Proteins c-fos (日) (読) [継承]
15. (英) Radioimmunoassay (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Sprague-Dawley (日) (読) [継承]
18. (英) Rats, Wistar (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 153 [継承]
(必須): 3 [継承]
(必須): 1377 1386 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 1月 17日 (平成 24年 1月 17日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2011-1539    (→Scopusで検索) [継承]
PMID (任意): 22253422    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-84857380269 [継承]
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被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroaki Fujihara, Kazuki Sasaki, Emi Mishiro-Sato, Toyoaki Ohbuchi, Govindan Dayanithi, Motoo Yamasaki, Yoichi Ueta and Naoto Minamino : Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat., Endocrinology, Vol.153, No.3, 1377-1386, 2012.
欧文冊子 ● Hiroaki Fujihara, Kazuki Sasaki, Emi Mishiro-Sato, Toyoaki Ohbuchi, Govindan Dayanithi, Motoo Yamasaki, Yoichi Ueta and Naoto Minamino : Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat., Endocrinology, Vol.153, No.3, 1377-1386, 2012.

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