『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=248142)

EID=248142EID:248142, Map:0, LastModified:2016年7月22日(金) 16:45:00, Operator:[福井 清], Avail:TRUE, Censor:0, Owner:[福井 清], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Kiso Kaori (日) (読)
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2. (英) Ueno Satoko (日) (読)
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[継承]
3. (英) Fukuda Mana (日) (読)
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[継承]
4. (英) Ichi Ikuyo (日) (読)
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[継承]
5. (英) Kobayashi Keiko (日) (読)
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6.坂井 隆志
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7.福井 清 ([徳島大学])
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8. (英) Kojo Shousuke (日) 小城 勝相 (読) こじょう しょうすけ
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題名 (必須): (英) The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Carbon tetrachloride (CCl(4))-induced acute hepatitis is assumed to involve two phases. The initial phase, initiated within 2 h after CCl(4) administration, involves the generation of reactive oxygen species. The second phase is assumed to start about 8 h subsequent to CCl(4) administration and involves the oxidant-induced activation of Kupffer cells, which release various pro-inflammatory mediators such as tumor necrosis factor- (TNF-) and interleukin-6 (IL-6). We investigated the role of Kupffer cells during CCl(4) intoxication using Nucling-knockout mice (the KO group), in which the number of Kupffer cells is largely reduced. Plasma alanine transaminase and aspartate transaminase levels demonstrated that the liver necrosis during the second phase was significantly alleviated in the KO group compared with that in the wild-type mice (the WT group). Plasma TNF- concentrations in the WT group significantly increased 24 h after CCl(4) intoxication, whereas those in the KO group did not significantly increase. Plasma IL-6 levels also significantly increased in the WT group 24 h after CCl(4) administration, but those in the KO group did not increase at any time point. These results indicated that excess reactions of Kupffer cells, once primed by oxidants, were involved in the exacerbation of oxidative stress and liver damage during the second phase of CCl(4) intoxication.  (日)    [継承]
キーワード (推奨): 1. (英) carbon tetrachloride (日) (読) [継承]
2. (英) Kupffer (日) (読) [継承]
3.ヌクリング (nucling) [継承]
4. (英) interleukin (日) (読) [継承]
5. (英) tumor necrosis factor (日) (読) [継承]
6.酸化ストレス (oxidative stress) [継承]
発行所 (推奨): 日本薬学会 [継承]
誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 1347-5215
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol. Pharm. Bull.
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 35 [継承]
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(必須): 980 983 [継承]
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年月日 (必須): 西暦 2012年 6月 1日 (平成 24年 6月 1日) [継承]
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DOI (任意): 10.1248/bpb.35.980    (→Scopusで検索) [継承]
PMID (任意): 22687543    (→Scopusで検索) [継承]
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WOS (任意): 000304722600029 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Food Science and Nutrition, Nara Women's University, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaori Kiso, Satoko Ueno, Mana Fukuda, Ikuyo Ichi, Keiko Kobayashi, Takashi Sakai, Kiyoshi Fukui and Shousuke Kojo : The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice, Biological & Pharmaceutical Bulletin, Vol.35, No.6, 980-983, 2012.
欧文冊子 ● Kaori Kiso, Satoko Ueno, Mana Fukuda, Ikuyo Ichi, Keiko Kobayashi, Takashi Sakai, Kiyoshi Fukui and Shousuke Kojo : The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice, Biological & Pharmaceutical Bulletin, Vol.35, No.6, 980-983, 2012.

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