『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=248137EID:248137, Map:0, LastModified:2012年8月29日(水) 17:08:12, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[工藤 保誠], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1. (英) Hatano H (日) (読)
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2.工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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3. (英) Ogawa I (日) (読)
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4. (英) Shimasue H (日) (読)
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5. (英) Shigeishi H (日) (読)
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6. (英) Ohta K (日) (読)
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7. (英) Higashikawa K (日) (読)
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8.武知 正晃
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9.高田 隆 ([広島大学])
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10.鎌田 伸之
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題名 (必須): (英) Establishment of mesenchymal cell line derived from human developing odontoma.  (日)    [継承]
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要約 (任意): (英)   (日) Oral Diseases (2012) Objectives: An odontoma, which shows proliferating odontogenic epithelium and mesenchymal tissue, is one of the most common odontogenic tumors encountered. These are commonly found in tooth-bearing regions, although the etiology remains unknown. There are no previous reports of an established line of immortalized human odontoma cells. Methods: Using odontoma fragments obtained from a girl treated at our department, we established an immortalized human odontoma cell line and investigated cell morphology, dynamic proliferation, the presence of contamination, and karyotype. Moreover, cell characterization was examined using osteogenic and odontogenic markers. Results: We successfully established a mesenchymal odontoma cell (mOd cells). The cells were found to be fibroblastic and had a high level of telomerase activity. Cell growth was confirmed after more than 200 population doublings without significant growth retardation. mOd cells expressed mRNA for differentiation markers, including collagen type I (COLI), alkaline phosphatase, bone sialoprotein, osteopontin, osteocalcin, cementum-derived protein (CP-23), dentin sialophosphoprotein (DSPP), and distal-less homeobox 3 (DLX3), as well as bone morphogenetic proteins (BMPs). In addition, they showed a high level of calcified nodule formation activity in vitro. Conclusions: We successfully established a cell line that may be useful for investigating the mechanisms of normal odontogenesis as well as characteristics of odontoma tumors.   [継承]
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誌名 (必須): Oral Diseases (Munksgaard)
(pISSN: 1354-523X, eISSN: 1601-0825)

ISSN (任意): 1601-0825
ISSN: 1354-523X (pISSN: 1354-523X, eISSN: 1601-0825)
Title: Oral diseases
Title(ISO): Oral Dis
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2012年 4月 24日 (平成 24年 4月 24日) [継承]
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DOI (任意): 10.1111/j.1601-0825.2012.01942.x    (→Scopusで検索) [継承]
PMID (任意): 22642601    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima Department of Oral and Maxillofacial Pathobiology, Graduate School, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● H Hatano, Yasusei Kudo, I Ogawa, H Shimasue, H Shigeishi, K Ohta, K Higashikawa, Masaaki Takechi, Takashi Takata and Nobuyuki Kamata : Establishment of mesenchymal cell line derived from human developing odontoma., Oral Diseases, (巻), (号), (頁), 2012.
欧文冊子 ● H Hatano, Yasusei Kudo, I Ogawa, H Shimasue, H Shigeishi, K Ohta, K Higashikawa, Masaaki Takechi, Takashi Takata and Nobuyuki Kamata : Establishment of mesenchymal cell line derived from human developing odontoma., Oral Diseases, (巻), (号), (頁), 2012.

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