『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.西庄 俊彦 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).脊椎関節機能再建外科学])
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2.油形 公則
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3.松井 好人
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4.松浦 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).脊椎関節機能再建外科学])
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5.東野 恒作
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6. (英) Suganuma K (日) 菅沼 勝義 (読) すがぬま かつよし
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7.二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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8.安井 夏生
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題名 (必須): (英) Angiogenesis and myogenesis in mouse tibialis anterior muscles during distraction osteogenesis: VEGF, its receptors, and myogenin genes expression.  (日)    [継承]
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要約 (任意): (英) Angiogenesis and myogenesis occur in the surrounding skeletal muscles following distraction osteogenesis, but their molecular mechanisms remain unclear. The present study investigated morphological features of lengthened muscles and the time course change of vascular endothelial growth factor (VEGF), its receptors (VEGFR-1 and VEGFR-2) and myogenin gene expression profiles related to angiogenesis and myogenesis in tibialis anterior (TA) muscles with a mouse model of distraction osteogenesis, which involves 1 week of waiting period (latency phase), 2 weeks of intermittent distraction (distraction phase), and 5 weeks of remodeling period (consolidation phase). Macroscopic findings showed that lengthened TA muscles increased to approximately 42% longer and 10% heavier at the end of the process when compared to pre-surgery. During the distraction phase, VEGF and its receptors were induced in the vascular endothelial cells, myogenin-positive satellite cells and myocytes, and subsequently, capillary progression and myogenesis were increased. Real-time RT-PCR showed that Vegf, Vegfr-1, Vegfr-2, and myogenin genes expression was enhanced during the muscle lengthening. Vegf and Vegfr-1 were upregulated following the recession of angiogenesis at the consolidation phase. We conclude that upregulation of VEGF and its receptors by mechanical tension-stress could be involved in the process of angiogenesis and myogenesis in lengthened muscles. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.  (日)    [継承]
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誌名 (必須): Journal of Orthopaedic Research (Bioelectric Repair and Growth Society/Orthopaedic Research Society)
(pISSN: 0736-0266, eISSN: 1554-527X)

ISSN (任意): 1554-527X
ISSN: 0736-0266 (pISSN: 0736-0266, eISSN: 1554-527X)
Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Title(ISO): J Orthop Res
Supplier: Orthopaedic Research Society
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 30 [継承]
(必須): 11 [継承]
(必須): 1767 1773 [継承]
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年月日 (必須): 西暦 2012年 4月 23日 (平成 24年 4月 23日) [継承]
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DOI (任意): 10.1002/jor.22136    (→Scopusで検索) [継承]
PMID (任意): 22528802    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1002/jor.22136  (日)    [継承]
2.(英) Article.Affiliation: Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Toshihiko Nishisho, Kiminori Yukata, Yoshito Matsui, Tetsuya Matsuura, Kousaku Higashino, K Suganuma, Takeshi Nikawa and Natsuo Yasui : Angiogenesis and myogenesis in mouse tibialis anterior muscles during distraction osteogenesis: VEGF, its receptors, and myogenin genes expression., Journal of Orthopaedic Research, Vol.30, No.11, 1767-1773, 2012.
欧文冊子 ● Toshihiko Nishisho, Kiminori Yukata, Yoshito Matsui, Tetsuya Matsuura, Kousaku Higashino, K Suganuma, Takeshi Nikawa and Natsuo Yasui : Angiogenesis and myogenesis in mouse tibialis anterior muscles during distraction osteogenesis: VEGF, its receptors, and myogenin genes expression., Journal of Orthopaedic Research, Vol.30, No.11, 1767-1773, 2012.

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