『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=245637EID:245637, Map:0, LastModified:2019年2月22日(金) 11:26:14, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[福井 清], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
2.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日/->組織[徳島大学.大学院医歯薬学研究部]) [継承]
著者 (必須): 1. (英) El-Sayed Mohamed Salah (日) (読) モハメド サラ
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学籍番号 (推奨): **** [ユーザ]
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2. (英) El-Magd Mohamed Abou Rabab (日) (読) エルマグド モハメド アブ ラバブ
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3.宍戸 裕二 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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4.鄭 丞弼
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5. (英) Tran Hong Diem (日) Tran Hong Diem (読) チャン ホン ディエム
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学籍番号 (推奨): **** [ユーザ]
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6.坂井 隆志
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7.渡邊 浩良 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
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8.香美 祥二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科])
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9.福井 清 ([徳島大学])
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題名 (必須): (英) 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects  (日)    [継承]
副題 (任意):
要約 (任意): (英) Oxidative stress-energy depletion therapy using oxidative stress induced by D-amino acid oxidase (DAO) and energy depletion induced by 3-bromopyruvate (3BP) was reported recently (El Sayed et al., Cancer Gene Ther., 19, 1-18, 2012). Even in the presence of oxygen, cancer cells oxidize glucose preferentially to produce lactate (Warburg effect) which seems vital for cancer microenvironment and progression. 3BP is a closely related structure to lactate and pyruvate and may antagonize their effects as a novel mechanism of its action. Pyruvate exerted a potent H(2)O(2) scavenging effect to exogenous H(2)O(2), while lactate had no scavenging effect. 3BP induced H(2)O(2) production. Pyruvate protected against H(2)O(2)-induced C6 glioma cell death, 3BP-induced C6 glioma cell death but not against DAO/D-serine-induced cell death, while lactate had no protecting effect. Lactate and pyruvate protected against 3BP-induced C6 glioma cell death and energy depletion which were overcome with higher doses of 3BP. Lactate and pyruvate enhanced migratory power of C6 glioma which was blocked by 3BP. Pyruvate and lactate did not protect against C6 glioma cell death induced by other glycolytic inhibitors e.g. citrate (inhibitor of phosphofructokinase) and sodium fluoride (inhibitor of enolase). Serial doses of 3BP were synergistic with citrate in decreasing viability of C6 glioma cells and spheroids. Glycolysis subjected to double inhibition using 3BP with citrate depleted ATP, clonogenic power and migratory power of C6 glioma cells. 3BP induced a caspase-dependent cell death in C6 glioma. 3BP was powerful in decreasing viability of human glioblastoma multiforme cells (U373MG) and C6 glioma in a dose- and time-dependent manner.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents, Alkylating (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Cell Survival (日) (読) [継承]
4. (英) Citric Acid (日) (読) [継承]
5.D-アミノ酸酸化酵素 (D-amino acid oxidase) [継承]
6. (英) Electrophoresis, Polyacrylamide Gel (日) (読) [継承]
7. (英) Glioblastoma (日) (読) [継承]
8. (英) Glioma (日) (読) [継承]
9. (英) Glycolysis (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.過酸化水素水 (hydrogen peroxide) [継承]
12. (英) Immunoblotting (日) (読) [継承]
13. (英) Lactic Acid (日) (読) [継承]
14.酸化ストレス (oxidative stress) [継承]
15. (英) Pyruvates (日) (読) [継承]
16. (英) Pyruvic Acid (日) (読) [継承]
17. (英) Tetrazolium Salts (日) (読) [継承]
18. (英) Thiazoles (日) (読) [継承]
発行所 (推奨): Springer New York [継承]
誌名 (必須): Journal of Bioenergetics and Biomembranes ([Springer-Verlag])
(pISSN: 0145-479X, eISSN: 1573-6881)

ISSN (任意): 1573-6881
ISSN: 0145-479X (pISSN: 0145-479X, eISSN: 1573-6881)
Title: Journal of bioenergetics and biomembranes
Title(ISO): J. Bioenerg. Biomembr.
Supplier: Kluwer Online
Publisher: Springer US
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年月日 (必須): 西暦 2012年 2月 1日 (平成 24年 2月 1日) [継承]
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DOI (任意): 10.1007/s10863-012-9409-4    (→Scopusで検索) [継承]
PMID (任意): 22318356    (→Scopusで検索) [継承]
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WOS (任意): 000301843000007 [継承]
Scopus (任意): 2-s2.0-84858749705 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10863-012-9409-4  (日)    [継承]
2.(英) Article.Affiliation: Division of Enzyme Pathophysiology, The Institute for Enzyme Research, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Salah Mohamed El-Sayed, Rabab Mohamed Abou El-Magd, Yuji Shishido, Seongpil Chung, Diem Hong Tran, Takashi Sakai, Hiroyoshi Watanabe, Shoji Kagami and Kiyoshi Fukui : 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects, Journal of Bioenergetics and Biomembranes, Vol.44, No.1, 61-79, 2012.
欧文冊子 ● Salah Mohamed El-Sayed, Rabab Mohamed Abou El-Magd, Yuji Shishido, Seongpil Chung, Diem Hong Tran, Takashi Sakai, Hiroyoshi Watanabe, Shoji Kagami and Kiyoshi Fukui : 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects, Journal of Bioenergetics and Biomembranes, Vol.44, No.1, 61-79, 2012.

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