『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.先端基礎医学教育研究プロジェクト (2005年1月1日〜2015年3月31日) [継承]
2.顕微解剖学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Awaad Aziz (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.中村 教泰
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.石村 和敬
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse in mouse Peyer's patches using fluorescent organosilica particles.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The size-dependent mucosal immunoresponse against nanomaterials (nanoimmunoresponse) is an important approach for mucosal vaccination. In the present work, the size-dependent nanoimmunoresponse of mouse Peyer's patches (PPs) and immunoglobulin A (IgA) level was investigated using fluorescent thiol-organosilica particles. Various sizes of fluorescent thiol-organosilica particles (100, 180, 365, 745, and 925 nm in diameter) were administered orally. PPs were analyzed histochemically, and IgA levels in PP homogenates, intestinal secretions around PPs, and bile were analyzed biochemically. When compared with the larger particles (745 and 925 nm), oral administration of smaller thiol-organosilica particles (100, 180, and 365 nm) increased the number of CD11b(+) macrophages and IgA(+) cells in the subepithelial domes of the PPs. Additionally, administration of larger particles induced the expression of alpha-L-fucose and mucosal IgA on the surface of M cells in the follicle-associated epithelia of PPs and increased the number of 33D1(+) dendritic cells in the subepithelial domes of the PPs. IgA contents in the bile and PP homogenates were high after the administration of the 100 nm particles, but IgA levels in the intestinal secretions were high after the administration of the 925 nm particles. Two size-dependent routes of IgA secretions into the intestinal lumen, the enterohepatic route for smaller particles and the mucosal route for larger particles were proposed. Thiol-organosilica particles demonstrated size-dependent nanoimmunoresponse after oral administration. The size of the particles may control the mucosal immunity in PPs and were useful in mucosal vaccination approaches.  (日)    [継承]
キーワード (推奨): 1. (英) Administration, Oral (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Female (日) (読) [継承]
4. (英) Fluorescent Dyes (日) (読) [継承]
5. (英) Immunity, Mucosal (日) (読) [継承]
6. (英) Immunoglobulin A, Secretory (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Inbred C57BL (日) (読) [継承]
9. (英) Microscopy, Fluorescence (日) (読) [継承]
10.ナノ医療 (nanomedicine) [継承]
11.ナノ粒子 (nanoparticles/->キーワード[ナノ粒子]) [継承]
12. (英) Organosilicon Compounds (日) (読) [継承]
13. (英) Particle Size (日) (読) [継承]
14. (英) Peyer's Patches (日) (読) [継承]
15. (英) Vaccines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Nanomedicine (American Society for Nanomedicine)
(pISSN: 1176-9114, eISSN: 1178-2013)

ISSN (任意): 1178-2013
ISSN: 1176-9114 (pISSN: 1176-9114, eISSN: 1178-2013)
Title: International journal of nanomedicine
Title(ISO): Int J Nanomedicine
Publisher: Dove Medical Press Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 7 [継承]
(必須): [継承]
(必須): 1423 1439 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 3月 13日 (平成 24年 3月 13日) [継承]
URL (任意):
DOI (任意): 10.2147/IJN.S28675    (→Scopusで検索) [継承]
PMID (任意): 22619503    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000302727500001 [継承]
Scopus (任意): 2-s2.0-84866754945 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2147/IJN.S28675  (日)    [継承]
2.(英) Article.Affiliation: Department of Anatomy and Cell Biology, the University of Tokushima Graduate School, Kuramoto, Tokushima, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: PMC3356209  (日)    [継承]

標準的な表示

和文冊子 ● Aziz Awaad, Michihiro Nakamura and Kazunori Ishimura : Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse in mouse Peyer's patches using fluorescent organosilica particles., International Journal of Nanomedicine, Vol.7, 1423-1439, 2012.
欧文冊子 ● Aziz Awaad, Michihiro Nakamura and Kazunori Ishimura : Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse in mouse Peyer's patches using fluorescent organosilica particles., International Journal of Nanomedicine, Vol.7, 1423-1439, 2012.

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