| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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| ○著者 (必須): | 1. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 奥村 裕司
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| ○学籍番号 (推奨): |
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| 3. | 高橋 悦久 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Pan Haiyan (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | Wang Siye
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| ○学籍番号 (推奨): |
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| 6. | Yao Dengbing
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| ○学籍番号 (推奨): |
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| 7. | Yao Min
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 千田 淳司 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 9. | 矢野 仁康
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since the IVA genome does not have the processing protease for the viral hemagglutinin (HA) envelope glycoprotein precursors, entry of this virus into cells and infectious organ tropism of IAV are primarily determined by host cellular trypsin-type HA processing proteases. Several secretion-type HA processing proteases for seasonal IAV in the airway, and ubiquitously expressed furin and pro-protein convertases for highly pathogenic avian influenza (HPAI) virus, have been reported. Recently, other HA-processing proteases for seasonal IAV and HPAI have been identified in the membrane fraction. These proteases proteolytically activate viral multiplication at the time of viral entry and budding. In addition to the role of host cellular proteases in IAV pathogenicity, IAV infection results in marked upregulation of cellular trypsins and matrix metalloproteinase-9 in various organs and cells, particularly endothelial cells, through induced pro-inflammatory cytokines. These host cellular factors interact with each other as the influenza virus-cytokine-protease cycle, which is the major mechanism that induces vascular hyperpermeability and multiorgan failure in severe influenza. This mini-review discusses the roles of cellular proteases in the pathogenesis of IAV and highlights the molecular mechanisms of upregulation of trypsins as effective targets for the control of IAV infection. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen Presentation (日) (読)
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| 3. | (英) Birds (日) (読)
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| 4. | (英) Capillary Permeability (日) (読)
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| 5. | (英) Host-Pathogen Interactions (日) (読)
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| 6. | (英) Humans (日) (読)
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| 7. | (英) Immune System (日) (読)
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| 8. | (英) Influenza A virus (日) (読)
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| 9. | (英) Influenza in Birds (日) (読)
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| 10. | (英) Influenza, Human (日) (読)
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| 11. | (英) Models, Biological (日) (読)
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| 12. | (英) Multiple Organ Failure (日) (読)
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| 13. | (英) Peptide Hydrolases (日) (読)
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| ○発行所 (推奨): | □ | Elsevier (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ([Elsevier Science])
(pISSN: 1570-9639, eISSN: 1878-1454)
| ○ISSN (任意): | □ | 1570-9639
ISSN: 1570-9639
(pISSN: 1570-9639, eISSN: 1878-1454) Title: Biochimica et biophysica acta. Proteins and proteomicsTitle(ISO): Biochim Biophys Acta Proteins ProteomPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 1824
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 186 194
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 1月 初日 (平成 24年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbapap.2011.07.001 (→Scopusで検索)
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| ○PMID (任意): | □ | 21801859 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.bbapap.2011.07.001 (日)
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| 2. | (英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuranmoto-cho, Tokushima, Japan. kido@ier.tokushima-u.ac.jp (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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