『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.化学応用工学科.物質合成化学講座 [継承]
2.物質変換化学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1.南川 慶二 ([徳島大学.教養教育院])
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[継承]
2. (英) Berber, Reda Mohamed (日) モハメド レダ バーバー (読) もはめど れだ ばーばー
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3. (英) Hafez, Hazzaa Inas (日) イナス ハザー ハフェズ (読) いなす はざー はふぇず
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[継承]
4.森 健
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学籍番号 (推奨):
[継承]
5.田中 正己 ([徳島文理大学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Target delivery and controlled release of the chemopreventive drug sulindac by using an advanced layered double hydroxide nanomatrix formulation system  (日)    [継承]
副題 (任意):
要約 (任意): (英) Target delivery and controlled release of the chemopreventive drug sulindac that possesses low water solubility present a great challenge for its pharmaceutical industry. Here, we offered an advanced nanomatrix formulation system of sulindac based on layered double hydroxide materials. The X-ray analysis and infrared spectroscopy confirmed the incorporation of sulindac into the gallery of the layered double hydroxides. The incorporation ratios of sulindac were recorded to be 45, 31 and 20 for coprecipitation, anion-exchange and reconstruction techniques, respectively. The scanning electron microscopy showed a nanomatrix-structure of ~50 nm. The release studies of sulindac-nanomatrix showed a 96% controlled release at the small intestine solution during 3 h(s), indicating an enhancement in the dissolution profile of sulindac after the matrix formation. The layered structure of the matrix supplied sulindac with a well-ordered structure and a relatively hydrophobic microenvironment that controlled the guest hydrolysis and reactivity during the release process. The laminar structure of layered double hydroxides offered a safe preservation for sulindac against photodecarboxylation, and enhanced the drug thermal stability from 190 to 230° C. The ionic electrostatic interaction of sulindac through its acidic group with layered double hydroxides demolished the gastrointestinal ulceration.  (日)    [継承]
キーワード (推奨): 1. (英) Anti-Inflammatory Agents, Non-Steroidal (日) (読) [継承]
2. (英) Anticarcinogenic Agents (日) (読) [継承]
3. (英) Chemistry, Pharmaceutical (日) (読) [継承]
4. (英) Drug Stability (日) (読) [継承]
5. (英) Hydroxides (日) (読) [継承]
6. (英) Microscopy, Electron, Scanning (日) (読) [継承]
7. (英) Nanoparticles (日) (読) [継承]
8. (英) Powder Diffraction (日) (読) [継承]
9. (英) Solubility (日) (読) [継承]
10. (英) Spectroscopy, Fourier Transform Infrared (日) (読) [継承]
11. (英) Sulindac (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Materials Science. Materials in Medicine (European Society for Biomaterials)
(pISSN: 0957-4530, eISSN: 1573-4838)

ISSN (任意): 1573-4838
ISSN: 0957-4530 (pISSN: 0957-4530, eISSN: 1573-4838)
Title: Journal of materials science. Materials in medicine
Title(ISO): J Mater Sci Mater Med
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 23 [継承]
(必須): 4 [継承]
(必須): 973 981 [継承]
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年月日 (必須): 西暦 2012年 2月 18日 (平成 24年 2月 18日) [継承]
URL (任意):
DOI (任意): 10.1007/s10856-012-4566-x    (→Scopusで検索) [継承]
PMID (任意): 22350776    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10856-012-4566-x  (日)    [継承]
2.(英) Article.Affiliation: Institute of Technology and Science, The University of Tokushima, Tokushima, Japan. minagawa@chem.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Keiji Minagawa, Mohamed Reda Berber, Inas Hazzaa Hafez, Takeshi Mori and Masami Tanaka : Target delivery and controlled release of the chemopreventive drug sulindac by using an advanced layered double hydroxide nanomatrix formulation system, Journal of Materials Science. Materials in Medicine, Vol.23, No.4, 973-981, 2012.
欧文冊子 ● Keiji Minagawa, Mohamed Reda Berber, Inas Hazzaa Hafez, Takeshi Mori and Masami Tanaka : Target delivery and controlled release of the chemopreventive drug sulindac by using an advanced layered double hydroxide nanomatrix formulation system, Journal of Materials Science. Materials in Medicine, Vol.23, No.4, 973-981, 2012.

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