『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=244352EID:244352, Map:0, LastModified:2017年12月4日(月) 13:59:30, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[野間 隆文], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.武藤 太郎
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2.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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3.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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4.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Dissection of morphological and metabolic differentiation of amelobrasts via ectopic SP6 expression  (日)    [継承]
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要約 (任意): (英) Tooth enamel is the hardest organ in the body. In rodent incisor, the enamel is exclusively produced by ameloblasts with yellowish-brown pigmentation, indicating normal enamel formation. However, the molecular mechanisms of ameloblast differentiation and amelogenesis are not fully understood. Specificity protein (Sp) 6 has been reported as one of the critical factors for tooth development. To explore SP6 function, we generated Sp6 transgenic (Tg) rats. Unexpectedly, the enamel surfaces of the incisors in Tg rats were discolored, even though enamel formation and serum iron concentrations were normal. Histological analysis of incisors from 6-week-old Tg rats demonstrated that the ameloblast layer at the pigmentation stage was elongated up to the gingival margin with ectopic SP6 expression in longitudinal incisor sections. In contrast, the incisors from 10-week-old Tg rats revealed that the pigmented ameloblasts were morphologically changed to those of the reduced stage, concomitant with the sporadic disappearance of ectopic SP6 expression. Here we report that morphological differentiation and metabolism of the iron-containing pigment in ameloblasts are independently regulated during amelogenesis by means of ectopic SP6 expression.  (日)    [継承]
キーワード (推奨): 1. (英) Ameloblasts (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Dental Enamel (日) (読) [継承]
5. (英) Dissection (日) (読) [継承]
6. (英) Kruppel-Like Transcription Factors (日) (読) [継承]
7. (英) Molar (日) (読) [継承]
8. (英) Rats (日) (読) [継承]
9. (英) Rats, Transgenic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 59 [継承]
(必須): 1-2 [継承]
(必須): 59 68 [継承]
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年月日 (必須): 西暦 2012年 2月 初日 (平成 24年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.59.59    (→Scopusで検索) [継承]
PMID (任意): 22449994    (→Scopusで検索) [継承]
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機関リポジトリ : 85239 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Biology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Taro Muto, Keiko Miyoshi, Taigo Horiguchi and Takafumi Noma : Dissection of morphological and metabolic differentiation of amelobrasts via ectopic SP6 expression, The Journal of Medical Investigation : JMI, Vol.59, No.1-2, 59-68, 2012.
欧文冊子 ● Taro Muto, Keiko Miyoshi, Taigo Horiguchi and Takafumi Noma : Dissection of morphological and metabolic differentiation of amelobrasts via ectopic SP6 expression, The Journal of Medical Investigation : JMI, Vol.59, No.1-2, 59-68, 2012.

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