『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=243435EID:243435, Map:0, LastModified:2012年9月19日(水) 13:59:14, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[漆原 真樹], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.漆原 真樹 ([徳島大学.病院.診療科.小児·周産·女性科.小児科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ohashi Naro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Miyata Kayoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Satou Ryousuke (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Acres Omar W (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kobori Hiroyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The monocyte chemoattractant protein-1 (MCP-1)/CC-chemokine receptor 2 (CCR2) pathway plays a critical role in the development of antiglomerular basement membrane (anti-GBM) nephritis. We recently showed angiotensin II (Ang II) infusion in rats activated MCP-1 and transforming growth factor-1 (TGF-1), which in turn induced macrophage infiltration of renal tissues. This study was performed to demonstrate that combination therapy with a CCR2 antagonist (CA) and an Ang II type 1 receptor blocker (ARB) ameliorated renal injury in the anti-GBM nephritis model. An anti-GBM nephritis rat model developed progressive proteinuria and glomerular crescent formation, accompanied by increased macrophage infiltration and glomerular expression of MCP-1, angiotensinogen, Ang II, and TGF-1. Treatment with CA alone or ARB alone moderately ameliorated kidney injury; however, the combination treatment with CA and ARB dramatically prevented proteinuria and markedly reduced glomerular crescent formation. The combination treatment also suppressed the induction of macrophage infiltration, MCP-1, angiotensinogen, Ang II, and TGF-1 and reversed the fibrotic change in the glomeruli. Next, primary cultured glomerular mesangial cells (MCs) stimulated by Ang II showed significant increases in MCP-1 and TGF-1 expression. Furthermore, cocultured model consisting of MCs, parietal epithelial cells, and macrophages showed an increase in Ang II-induced cell proliferation and collagen secretion. ARB treatment attenuated these augmentations. These data suggest that Ang II enhances glomerular crescent formation of anti-GBM nephritis. Moreover, our results demonstrate that inhibition of the MCP-1/CCR2 pathway with a combination of ARB effectively reduces renal injury in anti-GBM nephritis.  (日)    [継承]
キーワード (推奨): 1.分散分析 (analysis of variance) [継承]
2. (英) Angiotensin II (日) (読) [継承]
3. (英) Angiotensin II Type 1 Receptor Blockers (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Anti-Glomerular Basement Membrane Disease (日) (読) [継承]
6.血圧 (blood pressure) [継承]
7. (英) Cell Proliferation (日) (読) [継承]
8. (英) Chemokine CCL2 (日) (読) [継承]
9. (英) Disease Models, Animal (日) (読) [継承]
10. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) Kidney (日) (読) [継承]
13. (英) Macrophages (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Inbred WKY (日) (読) [継承]
17. (英) Receptors, CCR2 (日) (読) [継承]
18.レニン·アンジオテンシンシステム (Renin-angiotensin System) [継承]
19. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
20. (英) Transforming Growth Factor beta1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Hypertension ([American Heart Association])
(pISSN: 0194-911X, eISSN: 1524-4563)

ISSN (任意): 1524-4563
ISSN: 0194-911X (pISSN: 0194-911X, eISSN: 1524-4563)
Title: Hypertension (Dallas, Tex. : 1979)
Title(ISO): Hypertension
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 57 [継承]
(必須): 3 [継承]
(必須): 586 593 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 1月 31日 (平成 23年 1月 31日) [継承]
URL (任意):
DOI (任意): 10.1161/HYPERTENSIONAHA.110.165704    (→Scopusで検索) [継承]
PMID (任意): 21282555    (→Scopusで検索) [継承]
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Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● Maki Urushihara, Naro Ohashi, Kayoko Miyata, Ryousuke Satou, W Omar Acres and Hiroyuki Kobori : Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis., Hypertension, Vol.57, No.3, 586-593, 2011.
欧文冊子 ● Maki Urushihara, Naro Ohashi, Kayoko Miyata, Ryousuke Satou, W Omar Acres and Hiroyuki Kobori : Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis., Hypertension, Vol.57, No.3, 586-593, 2011.

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