| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 塩田 あすか
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| 2. | 竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| 3. | 前川 洋一
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| 4. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 5. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 6. | 酒井 徹 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])
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| 7. | (英) Mizuno, R. (日) (読)
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| 8. | (英) Isshiki, M. (日) (読)
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| 9. | 山本 浩範
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| 10. | 武田 英二
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| ○題名 (必須): | □ | (英) High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice. (日)
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| ○要約 (任意): | □ | (英) Although higher serum phosphate level is a risk factor for cardiovascular diseases in general population as well as chronic kidney disease patients, it has not been clarified whether higher phosphate can affect atherosclerotic plaque formation. In this study, we investigated the effect of prolonged-intake of different concentrations of phosphate on atherosclerosis formation using apolipoprotein E-deficient mice. Apolipoprotein E-deficient mice were fed with high fat diet including 0.6%, 1.2% or 1.8% phosphate. After 20-week treatment, atherosclerotic plaque formation in aorta in 1.8% phosphate diet group was unexpectedly less than that in the other groups. To elucidate mechanisms of suppression of plaque formation by high phosphate diet, we hypothesized that high phosphate diet may modify a profile of monocytes/macrophages suppressing plaque formation. We confirmed that elevated peripheral monocytes (CD11b+, F4/80+ cell numbers) in apolipoprotein E-deficient mice were decreased by feeding with 1.8% P diet. In addition, ex vivo study indicated that high dose of phosphate induced macrophage apoptosis. These observations suggest that excess phosphate intake decreased atherosclerosis formation, at least in part, by changing the profile of peripheral monocytes or inducing apoptosis of macrophages in apolipoprotein E-deficient mice. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | (英) (日) 日本酸化ストレス学会 (読)
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| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 1880-5086
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: The Society for Free Radical Research Japan (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 109 114
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| ○都市 (任意): | □ | 京都 (Kyoto/[日本国])
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| ○年月日 (必須): | □ | 西暦 2011年 9月 初日 (平成 23年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.10-150 (→Scopusで検索)
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| ○PMID (任意): | □ | 21980226 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC3171687 (日)
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