『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=241441)

EID=241441EID:241441, Map:0, LastModified:2018年5月4日(金) 17:09:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北岡 和義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.北岡 和義 ([徳島大学.教養教育院])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Shimizu Mika (日) 清水 美佳 (読) しみず みか
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
3. (英) Shimizu Noriyuki (日) 清水 紀之 (読) しみず のりゆき
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
4.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Nakagomi Madoka (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Shudo Koichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.吉﨑 和男
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Vitamin A is a common lipophilic vitamin, and its function is mainly mediated by the binding of its metabolite retinoic acid to retinoic acid receptors (RARs) and retinoid X receptors. Recently, it was reported that the expression of the RARb (an RAR subtype) gene determines the contribution of the delta oscillation in the sleep electroencephalogram (EEG) patterns in mice. We also reported that 4-week dietary deficiency of vitamin A (VAD) causes the attenuation of delta power in sleep and spontaneous activity in mice. However, our previous study could not clarify whether the attenuation of delta power by VAD is attributed to the suppression of RARs. To address this problem, we investigated whether the chronic administration of LE540 (30mg/kg/day), an antagonist of RARs, for 1 or 4weeks attenuated EEG delta power during sleep in mice. Consequently, 4-week LE540 administration induced a significant attenuation of wakefulness and delta power in non-rapid eye movement sleep. Western blot analysis revealed a significant decrease in the expression of dopamine D1 receptor (D1DR) in the striatum and tyrosine hydroxylase in the midbrain of mice that were administered LE540 for 4weeks. High-performance liquid chromatography analysis of striatal tissue revealed a significant decrease in the homovanillic acid/dopamine ratio. Meanwhile, dopamine levels did not change in these mice. Our results suggest that the 4-week antagonism of RARs induces the attenuation of delta power. However, the attenuation of delta power may be elicited indirectly by the decrease of wakefulness followed by the hypo-expression of dopamine receptors especially D1DR.  (日)    [継承]
キーワード (推奨): 1. (英) 3,4-Dihydroxyphenylacetic Acid (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Corpus Striatum (日) (読) [継承]
4. (英) Delta Rhythm (日) (読) [継承]
5. (英) Dibenzazepines (日) (読) [継承]
6. (英) Dopamine (日) (読) [継承]
7. (英) Electroencephalography (日) (読) [継承]
8. (英) Gene Expression Regulation (日) (読) [継承]
9. (英) Homovanillic Acid (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Receptors, Dopamine D1 (日) (読) [継承]
14. (英) Receptors, Retinoic Acid (日) (読) [継承]
15. (英) Sleep Stages (日) (読) [継承]
16. (英) Time Factors (日) (読) [継承]
17. (英) Wakefulness (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Brain Research ([Elsevier Science])
(pISSN: 0006-8993, eISSN: 1872-6240)

ISSN (任意): 1872-6240
ISSN: 0006-8993 (pISSN: 0006-8993, eISSN: 1872-6240)
Title: Brain research
Title(ISO): Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 1423 [継承]
(必須): [継承]
(必須): 10 16 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 11月 14日 (平成 23年 11月 14日) [継承]
URL (任意):
DOI (任意): 10.1016/j.brainres.2011.09.023    (→Scopusで検索) [継承]
PMID (任意): 22000589    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000297232700002 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. kitaoka@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice, Brain Research, Vol.1423, 10-16, 2011.
欧文冊子 ● Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice, Brain Research, Vol.1423, 10-16, 2011.

関連情報

Number of session users = 1, LA = 0.23, Max(EID) = 362759, Max(EOID) = 970276.