『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 著書 [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamamoto Sohei (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Tsuda Hitoshi (日) (読)
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[継承]
3. (英) Honda Kazufumi (日) (読)
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[継承]
4. (英) Takano Masashi (日) (読)
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[継承]
5. (英) Tamai Seiichi (日) (読)
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6.井本 逸勢
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7. (英) Inazawa Johji (日) (読)
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8. (英) Yamada Tesshi (日) (読)
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[継承]
9. (英) Matsubara Osamu (日) (読)
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題名 (必須): (英) ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Actinin-4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the actin cytoskeleton. We assessed how ACTN4/actinin-4 alterations contribute to the tumorigenesis of ovarian clear-cell adenocarcinomas (CCAs). Fluorescence in-situ hybridization analysis demonstrated that ACTN4 amplification (≥4 ACTN4 copies in ≥40% of cells) occurred in 27 (33%) of 81 CCAs and genomic gains of ACTN4 were associated strongly with immunohistochemical actinin-4 overexpression, poorly differentiated tumour histology and shorter patient survival (all P < 0.05). From the 27 ACTN4-amplified CCAs, 23 tumours with adjacent putative precursor lesions were selected and examined for ACTN4/actinin-4 alterations with respect to their intratumoral heterogeneity. In this selected cohort, none of the precursors lacking cytological atypia exhibited gains of ACTN4 or actinin-4 overexpression; 50% of the atypical endometrioses and 75% of the borderline CCAFs showed low-level gains of ACTN4 and actinin-4 overexpression, respectively. In 12 of 23 ACTN4-amplified CCAs, intratumoral heterogeneity for ACTN4 alterations was documented in carcinomatous components; the better differentiated carcinoma components exhibited fewer alterations than those with poorly differentiated histology. Accumulative genomic gains of ACTN4, causing actinin-4 protein overexpression, drive the development and progression of ovarian CCAs with high-grade histology.  (日)    [継承]
キーワード (推奨): 1. (英) Actinin (日) (読) [継承]
2. (英) Adenocarcinoma, Clear Cell (日) (読) [継承]
3. (英) Adenofibroma (日) (読) [継承]
4. (英) Adult (日) (読) [継承]
5. (英) Aged (日) (読) [継承]
6. (英) Disease Progression (日) (読) [継承]
7. (英) Endometriosis (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Gene Amplification (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) In Situ Hybridization, Fluorescence (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Neoplasm Invasiveness (日) (読) [継承]
15. (英) Ovarian Neoplasms (日) (読) [継承]
16. (英) Up-Regulation (日) (読) [継承]
発行所 (必須):
誌名 (任意): Histopathology (International Academy of Pathology. British Division)
(pISSN: 0309-0167, eISSN: 1365-2559)

ISSN (任意): 1365-2559
ISSN: 0309-0167 (pISSN: 0309-0167, eISSN: 1365-2559)
Title: Histopathology
Title(ISO): Histopathology
Supplier: British Division of the International Academy of Pathology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(任意): 60 [継承]
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(任意): 1073 1083 [継承]
都市 (必須):
年月日 (必須): 西暦 2012年 2月 20日 (平成 24年 2月 20日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2559.2011.04163.x    (→Scopusで検索) [継承]
PMID (任意): 22348389    (→Scopusで検索) [継承]
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WOS (任意): 000304344300006 [継承]
Scopus (任意): 2-s2.0-84863398440 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/j.1365-2559.2011.04163.x  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sohei Yamamoto, Hitoshi Tsuda, Kazufumi Honda, Masashi Takano, Seiichi Tamai, Issei Imoto, Johji Inazawa, Tesshi Yamada and Osamu Matsubara : ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas., (発行所), (都市), Feb. 2012.
欧文冊子 ● Sohei Yamamoto, Hitoshi Tsuda, Kazufumi Honda, Masashi Takano, Seiichi Tamai, Issei Imoto, Johji Inazawa, Tesshi Yamada and Osamu Matsubara : ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas., (発行所), (都市), Feb. 2012.

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