| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士後期課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医学研究科.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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| ○学籍番号 (推奨): |
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| 2. | 粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| ○学籍番号 (推奨): |
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| 3. | (英) Sato Takashi (日) (読)
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| ○貢献度 (任意): |
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| 4. | 赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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| ○学籍番号 (推奨): |
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| 5. | 吉栖 正典
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| 6. | (英) Suzaki Yuki (日) (読)
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| 7. | 石澤 有紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学]/->個人[井澤 有紀])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | (英) Fujimura Mitsunori (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 9. | (英) Hashizume Shunji (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 10. | (英) Kato Midori (日) (読)
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| 11. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 玉置 俊晃
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Kawano Hirotaka (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 14. | 松本 高広 ([徳島大学.先端研究推進センター.動物資源研究部門]/[徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター.動物資源研究部門])
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| ○学籍番号 (推奨): |
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| 15. | 東 博之
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| 16. | (英) Kato Shigeaki (日) (読)
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| ○貢献度 (任意): |
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| 17. | 松本 俊夫
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Androgen has anabolic effects on cardiac myocytes and has been shown to enhance left ventricular enlargement and function. However, the physiological and patho-physiological roles of androgen in cardiac growth and cardiac stress-induced remodeling remains unclear. We aimed to clarify whether the androgen-nuclear androgen receptor (AR) system contributes to the cardiac growth and angiotensin II (Ang II)-stimulated cardiac remodeling by using systemic AR-null male mice. AR knock-out (ARKO) male mice, at 25 weeks of age, and age-matched wild-type (WT) male mice were treated with or without Ang II stimulation (2.0 mg/kg/day) for 2 weeks. ARKO mice with or without Ang II stimulation showed a significant reduction in the heart-to-body weight ratio compared with those of WT mice. In addition, echocardiographic analysis demonstrated impairments of both the concentric hypertrophic response and left ventricular function in Ang II-stimulated ARKO mice. Western blot analysis of the myocardium revealed that activation of extracellular signal-regulated kinases (ERK) 1/2 and ERK5 by Ang II stimulation were lower in ARKO mice than those of WT mice. Ang II stimulation caused more prominent cardiac fibrosis in ARKO mice than in WT mice with enhanced expression of types I and III collagen and transforming growth factor-beta1 genes and with increased Smad2 activation. These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress. (日)
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| ○キーワード (推奨): | 1. | (英) Angiotensin II (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | 血圧 (blood pressure)
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| 4. | (英) Cardiomegaly (日) (読)
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| 5. | (英) DNA-Binding Proteins (日) (読)
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| 6. | 肺線維症 (pulmonary fibrosis)
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| 7. | (英) Heart Rate (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred C57BL (日) (読)
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| 11. | (英) Mice, Inbred CBA (日) (読)
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| 12. | ノックアウトマウス (knockout mice)
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| 13. | (英) Mitogen-Activated Protein Kinase 1 (日) (読)
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| 14. | (英) Mitogen-Activated Protein Kinase 3 (日) (読)
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| 15. | (英) Mitogen-Activated Protein Kinase 7 (日) (読)
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| 16. | 心筋 (myocardium)
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| 17. | (英) RNA, Messenger (日) (読)
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| 18. | (英) Receptors, Androgen (日) (読)
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| 19. | (英) Smad2 Protein (日) (読)
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| 20. | (英) Trans-Activators (日) (読)
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| 21. | (英) Transforming Growth Factor beta (日) (読)
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| 22. | (英) Transforming Growth Factor beta1 (日) (読)
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| 23. | (英) Ventricular Remodeling (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)
| ○ISSN (任意): | □ | 0021-9258
ISSN: 0021-9258
(pISSN: 0021-9258, eISSN: 1083-351X) Title: The Journal of biological chemistryTitle(ISO): J Biol ChemPublisher: American Society for Biochemistry and Molecular Biology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 280
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| ○号 (必須): | □ | 33
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| ○頁 (必須): | □ | 29661 29666
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 6月 16日 (平成 17年 6月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1074/jbc.M411694200 (→Scopusで検索)
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| ○PMID (任意): | □ | 15961403 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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