『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Murashima Aki (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Miyagawa Shinichi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Ogino Yukiko (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Nishida-Fukuda Hisayo (日) (読)
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[継承]
5. (英) Araki Kimi (日) (読)
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[継承]
6.松本 高広 ([徳島大学.先端研究推進センター.動物資源研究部門]/[徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター.動物資源研究部門])
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学籍番号 (推奨):
[継承]
7. (英) Kaneko Takehito (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Yoshinaga Kazuya (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Yamamura Ken-ichi (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Kurita Takeshi (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Kato Shigeaki (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Moon Anne M (日) (読)
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学籍番号 (推奨):
[継承]
13. (英) Yamada Gen (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation.  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) The epididymis is a male accessory organ and functions for sperm maturation and storage under the control of androgen. The development of the epididymis is also androgen dependent. The Wolffian duct (WD), anlagen of the epididymis, is formed in both male and female embryos; however, it is stabilized only in male embryos by testicular androgen. Androgen drives subsequent differentiation of the WD into the epididymis. Although the essential roles of androgen in WD masculinization and epididymal function have been established, little is known about cellular events regulated precisely by androgen signaling during these processes. It is also unclear whether androgen signaling, especially in the epithelia, has further function for epididymal epithelial cell differentiation. In this study we examined the cellular death and proliferation controlled by androgen signaling via the androgen receptor (AR) in WD stabilization. Analyses using AR knockout mice revealed that androgen signaling inhibits epithelial cell death in this process. Analysis of AP2α-Cre;AR(flox/Y) mice, in which AR function is deleted in the WD epithelium, revealed that epithelial AR is not required for the WD stabilization but is required for epithelial cell differentiation in the epididymis. Specifically, loss of epithelial AR significantly reduced expression of p63 that is essential for differentiation of basal cells in the epididymal epithelium. We also interrogated the possibility of regulation of the p63 gene (Trp63) by AR in vitro and found that p63 is a likely direct target of AR regulation.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Epididymis (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Knockout (日) (読) [継承]
11. (英) Mice, Nude (日) (読) [継承]
12. (英) Phosphoproteins (日) (読) [継承]
13. (英) Pregnancy (日) (読) [継承]
14. (英) Receptors, Androgen (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Trans-Activators (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 152 [継承]
(必須): 4 [継承]
(必須): 1640 1651 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 2月 8日 (平成 23年 2月 8日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2010-1121    (→Scopusで検索) [継承]
PMID (任意): 21303954    (→Scopusで検索) [継承]
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WOS (任意): 000288696300044 [継承]
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備考 (任意): 1.(英) Affiliation: Institute of Molecular Embryology and Genetics, Graduate School of Medical and Pharmaceutical Sciences, Global Center of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860-0811, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Aki Murashima, Shinichi Miyagawa, Yukiko Ogino, Hisayo Nishida-Fukuda, Kimi Araki, Takahiro Matsumoto, Takehito Kaneko, Kazuya Yoshinaga, Ken-ichi Yamamura, Takeshi Kurita, Shigeaki Kato, M Anne Moon and Gen Yamada : Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation., Endocrinology, Vol.152, No.4, 1640-1651, 2011.
欧文冊子 ● Aki Murashima, Shinichi Miyagawa, Yukiko Ogino, Hisayo Nishida-Fukuda, Kimi Araki, Takahiro Matsumoto, Takehito Kaneko, Kazuya Yoshinaga, Ken-ichi Yamamura, Takeshi Kurita, Shigeaki Kato, M Anne Moon and Gen Yamada : Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation., Endocrinology, Vol.152, No.4, 1640-1651, 2011.

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