『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=240732EID:240732, Map:0, LastModified:2018年4月26日(木) 21:55:22, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[小山 保夫], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士前期課程学生による研究報告 [継承]
組織 (推奨): 1.徳島大学.総合科学教育部.地域科学専攻.環境共生分野 (2009年4月1日〜) [継承]
2.徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部.創生科学研究部門.環境共生科学分野 (2009年4月1日〜2016年3月31日) [継承]
著者 (必須): 1.田村 生弥 (徳島大学大学院総合科学教育部地域科学専攻)
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学籍番号 (推奨): **** [ユーザ]
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2. (英) Saito Minoru (日) 齋藤 稔 (読) さいとう みのる
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学籍番号 (推奨): **** [ユーザ]
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3. (英) Nishimura Yumiko (日) (読)
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4.佐藤 征弥 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.生物生産系.生物資源生産科学分野]/[徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部.創生科学研究部門.環境共生科学分野]/[徳島大学.総合科学部.社会創生学科.環境共生コース])
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5.山本 裕史
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6.小山 保夫
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題名 (必須): (英) Elevation of intracellular Ca2+ level by triclosan in rat thymic lymphocytes: Increase in membrane Ca2+ permeability and induction of intracellular Ca2+ release  (日)    [継承]
副題 (任意):
要約 (任意): (英) Triclosan is an antibacterial agent used in household items and personal care products. Because wild animals and humans can harbor this compound in their systems, the toxic effects of triclosan are a possibility and are suspected. Therefore, we examined the effects of triclosan on intracellular Ca2+ concentration in rat thymocytes by cytometric techniques using fluorescent probes. Triclosan doses of 1 10 µM significantly increased the intensity of Ca2+-detecting Fluo-3 fluorescence, indicating an increase in intracellular Ca2+ concentrations. The augmentation of Fluo-3 fluorescence became more profound in a dose-dependent manner after the addition of an external source of Ca2+. Conversely, the removal of external Ca2+ greatly attenuated the triclosan-induced augmentation of Fluo-3 fluorescence. These results suggest that triclosan treatment allows external Ca2+ to pass through cell membranes. This phenomenon was not specific for Ca2+ because external Mn2+ quenched the triclosan-induced augmentation of Fluo-3 fluorescence, indicating that triclosan can also mediate Mn2+ permeation across membranes. Therefore, these results suggest that triclosan increases membrane permeability to divalent metal cations. Furthermore, triclosan induces Ca2+ release from intracellular stores because the Fluo-3 fluorescence intensity still increased slightly after triclosan treatment, even under conditions free from external Ca2+. Additionally, triclosan did not increase the intensity of Fluo-3 fluorescence when Ca2+ was depleted from intracellular Ca2+ stores by A23187 under the external Ca2+-free condition. Taken together, these data suggest that micromolar concentrations of triclosan affect intracellular Ca2+ homeostasis in thymocytes, possibly resulting in cellular malfunction.  (日)    [継承]
キーワード (推奨): 1. (英) triclosan (日) (読) [継承]
2. (英) Ca (日) (読) [継承]
3. (英) Fluo-3 (日) (読) [継承]
4. (英) thymocyte (日) (読) [継承]
発行所 (推奨): 日本薬学会 [継承]
誌名 (必須): Journal of Health Science ([日本薬学会])
(pISSN: 1344-9702, eISSN: 1347-5207)

ISSN (任意): 1347-5207
ISSN: 1344-9702 (pISSN: 1344-9702, eISSN: 1347-5207)
Title: Journal of health science (Tokyo, Japan)
Title(ISO): J Health Sci
Supplier: 公益社団法人日本薬学会
Publisher: African Forum for Health Sciences
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 57 [継承]
(必須): 6 [継承]
(必須): 540 546 [継承]
都市 (任意): 東京 (Tokyo/[日本国]) [継承]
年月日 (必須): 西暦 2011年 12月 末日 (平成 23年 12月 末日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/40019073438/ [継承]
DOI (任意): 10.1248/jhs.57.540    (→Scopusで検索) [継承]
PMID (任意):
NAID (任意): 40019073438 [継承]
WOS (任意): 000297400100010 [継承]
Scopus (任意): 2-s2.0-82855178905 [継承]
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標準的な表示

和文冊子 ● Ikumi Tamura, Minoru Saito, Yumiko Nishimura, Masaya Satoh, Hiroshi Yamamoto and Yasuo Oyama : Elevation of intracellular Ca2+ level by triclosan in rat thymic lymphocytes: Increase in membrane Ca2+ permeability and induction of intracellular Ca2+ release, Journal of Health Science, Vol.57, No.6, 540-546, 2011.
欧文冊子 ● Ikumi Tamura, Minoru Saito, Yumiko Nishimura, Masaya Satoh, Hiroshi Yamamoto and Yasuo Oyama : Elevation of intracellular Ca2+ level by triclosan in rat thymic lymphocytes: Increase in membrane Ca2+ permeability and induction of intracellular Ca2+ release, Journal of Health Science, Vol.57, No.6, 540-546, 2011.

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