| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜)
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| 2. | 広島大学
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| ○著者 (必須): | 1. | 谷本 幸太郎 ([広島大学])
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| 2. | (英) Yanagida T (日) (読)
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| 3. | (英) Tanne Y (日) (読)
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| 4. | (英) Kamiya T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | (英) Huang Y-C (日) (読)
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| ○貢献度 (任意): |
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| 6. | (英) Mitsuyoshi T (日) (読)
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| ○貢献度 (任意): |
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| 7. | (英) Tanaka N (日) (読)
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| 8. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| 9. | 丹根 一夫 ([広島大学])
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) Modulation of hyaluronan fragmentation by interleukin-1β in synovial membrane cells (日)
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| ○要約 (任意): | □ | (英) Hyaluronan (HA) plays a crucial role in the lubricating and buffering properties of synovial fluid. The purpose of this study was to examine the effects of interleukin (IL)-1beta on HA degradation in cultured synovial membrane cells. The rabbit synovial membrane cell line HIG-82 was cultured with and without IL-1beta. The amounts of HA of varying molecular weights in the medium were analyzed using high-performance liquid chromatography, the mRNA levels of HA synthase (HAS) and hyaluronidase (HYAL) were analyzed by means of real-time PCR, and HYAL activity was analyzed by HA zymography. The amounts of HA with a molecular weight lower than 300 kDa, and between 300 and 1900 kDa, in the culture medium of HIG-82 cells were significantly higher in the presence of IL-1beta. However, the amount of HA with a molecular weight greater than 1900 kDa was significantly lower in the presence of IL-1beta. Both HAS2 and HAS3 mRNA levels were upregulated by treatment with IL-1beta. So, too, were the levels of HYAL1 and HYAL2 mRNA, which resulted in enhanced HYAL activity. However, HYAL activity was inhibited by transfection of HYAL2-siRNA. Our results suggest that IL-1beta is a crucial factor in the fragmentation of HA in inflammatory joints. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | (英) Dose-Response Relationship, Drug (日) (読)
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| 4. | (英) Hyaluronic Acid (日) (読)
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| 5. | (英) Interleukin-1 (日) (読)
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| 6. | (英) Rabbits (日) (読)
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| 7. | (英) Signal Transduction (日) (読)
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| 8. | (英) Synovial Membrane (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)
| ○ISSN (任意): | □ | 1573-9686
ISSN: 0090-6964
(pISSN: 0090-6964, eISSN: 1573-9686) Title: Annals of biomedical engineeringTitle(ISO): Ann Biomed EngSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 38
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1618 1625
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 4月 末日 (平成 22年 4月 末日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10439-010-9927-3 (→Scopusで検索)
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| ○PMID (任意): | □ | 20099033 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. tkotaro@hiroshima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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