『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=237480)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Terawaki Seigo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Chikuma Shunsuke (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Shibayama Shiro (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Hayashi Tamon (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yoshida Takao (日) (読)
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学籍番号 (推奨):
[継承]
6.岡崎 拓
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Honjo Tasuku (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) IFN- directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Programmed cell death-1 (PD-1) is an inhibitory coreceptor for T lymphocytes that provides feedback inhibition of T cell activation. Although PD-1's expression on T cells is known to be activation dependent, the factors that determine the timing, intensity, and duration of PD-1 expression in immune reactions are not fully understood. To address this question, we performed a fine mapping analysis of a conserved 5'-flanking region of the PD-1 gene and identified a putative IFN stimulation response element, which was responsible for PD-1 transcription in the 2B4.11 T cell line. Consistent with this finding, activation by IFN- enhanced both the induction and maintenance of PD-1 expression on TCR-engaged primary mouse T cells through an association IFN-responsive factor 9 (IRF9) to the IFN stimulation response element. Furthermore, PD-1 expression on Ag-specific CD8(+) T cells was augmented by IFN- in vivo. We propose that strong innate inflammatory responses promote primary T cell activation and their differentiation into effector cells, but also cause an attenuated T cell response in sustained immune reactions, at least partially through type I IFN-mediated PD-1 transcription. Based on this idea, we demonstrate that IFN- administration in combination with PD-1 blockade in tumor-bearing mice effectively augments the antitumor immunity, and we propose this as a novel and rational approach for cancer immunotherapy.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, Surface (日) (読) [継承]
3. (英) Apoptosis Regulatory Proteins (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Immunity, Cellular (日) (読) [継承]
9. (英) Interferon-Stimulated Gene Factor 3, gamma Subunit (日) (読) [継承]
10. (英) Interferon-alpha (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred BALB C (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Mice, Knockout (日) (読) [継承]
15. (英) Mice, Transgenic (日) (読) [継承]
16. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
17. (英) Regulatory Elements, Transcriptional (日) (読) [継承]
18. (英) Signal Transduction (日) (読) [継承]
19. (英) T-Lymphocyte Subsets (日) (読) [継承]
20. (英) Transcription, Genetic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 186 [継承]
(必須): 5 [継承]
(必須): 2772 2779 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 1月 24日 (平成 23年 1月 24日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1003208    (→Scopusで検索) [継承]
PMID (任意): 21263073    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe, Sakyo-Ku, Kyoto 606-8501, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Seigo Terawaki, Shunsuke Chikuma, Shiro Shibayama, Tamon Hayashi, Takao Yoshida, Taku Okazaki and Tasuku Honjo : IFN- directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity., The Journal of Immunology, Vol.186, No.5, 2772-2779, 2011.
欧文冊子 ● Seigo Terawaki, Shunsuke Chikuma, Shiro Shibayama, Tamon Hayashi, Takao Yoshida, Taku Okazaki and Tasuku Honjo : IFN- directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity., The Journal of Immunology, Vol.186, No.5, 2772-2779, 2011.

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