『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.森田 恭二
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2. (英) Hamano Shuichi (日) (読)
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3.東 満美
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4. (英) Oka Motoo (日) (読)
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題名 (必須): (英) Ca2+ inactivation of voltage-dependent Na+ channels in cultured bovine adrenal chromaffin cells  (日)    [継承]
副題 (任意): (英) Further studies on inhibition of veratridine-induced catecholamine secretion by external Ca2+.  (日)    [継承]
要約 (任意): (英) The stimulatory actions of veratridine (VTD) on catecholamine secretion and Na+ influx in cultured bovine adrenal chromaffin cells were studied in the presence of high concentrations of Ca2+ in the incubation mixture. Catecholamine secretion evoked by VTD was reduced by elevating the external Ca2+ concentration to higher than 2 mM. Under the same conditions, VTD-stimulated 22Na+ uptake into the cells was also reduced by elevating the extracellular Ca2+ concentration. In contrast, the secretory action of VTD was not significantly suppressed by preloading Ca2+ to the cells. Furthermore, the effects of extracellular Ca2+ on the sensitivities of the cells to VTD and tetrodotoxin (TTX) were examined, and neither their sensitivities to VTD nor those to TTX were shown to be significantly altered by elevating the Ca2+ concentration in the incubation mixture. These results seem to indicate that the elevation of extracellular Ca2+ concentration may cause the inhibition of VTD-induced catecholamine secretion as a consequence of the inactivation of voltage-dependent Na+ channels, and suggest that Ca2+ may directly act on the cell surface, and the site of Ca2+ action is presumably distinct from the sites of both VTD and TTX actions in the plasma membranes of adrenal chromaffin cells.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenal Medulla (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3.カルシウム (calcium) [継承]
4. (英) Catecholamines (日) (読) [継承]
5. (英) Cattle (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Dose-Response Relationship, Drug (日) (読) [継承]
8. (英) Sodium (日) (読) [継承]
9. (英) Sodium Channels (日) (読) [継承]
10. (英) Tetrodotoxin (日) (読) [継承]
11. (英) Veratridine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Japanese Journal of Pharmacology ([日本薬理学会])
(pISSN: 0021-5198, eISSN: 1347-3506)

ISSN (任意): 0021-5198
ISSN: 0021-5198 (pISSN: 0021-5198, eISSN: 1347-3506)
Title: Japanese journal of pharmacology
Title(ISO): Jpn. J. Pharmacol.
Supplier: 公益社団法人 日本薬理学会
Publisher: Japanese Pharmacological Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 201 207 [継承]
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年月日 (必須): 西暦 1994年 7月 初日 (平成 6年 7月 初日) [継承]
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DOI (任意): 10.1254/jjp.65.201    (→Scopusで検索) [継承]
PMID (任意): 7799520    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Shuichi Hamano, Mami Azuma and Motoo Oka : Ca2+ inactivation of voltage-dependent Na+ channels in cultured bovine adrenal chromaffin cells, --- Further studies on inhibition of veratridine-induced catecholamine secretion by external Ca2+. ---, The Japanese Journal of Pharmacology, Vol.65, No.3, 201-207, 1994.
欧文冊子 ● Kyoji Morita, Shuichi Hamano, Mami Azuma and Motoo Oka : Ca2+ inactivation of voltage-dependent Na+ channels in cultured bovine adrenal chromaffin cells, --- Further studies on inhibition of veratridine-induced catecholamine secretion by external Ca2+. ---, The Japanese Journal of Pharmacology, Vol.65, No.3, 201-207, 1994.

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