『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=237392EID:237392, Map:0, LastModified:2017年12月4日(月) 13:57:44, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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著者 (必須): 1. (英) Tamagawa Kazuhiko (日) (読)
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2.中山 治之
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3. (英) Wakimoto Shin (日) (読)
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4. (英) Ichimura Minoru (日) (読)
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5.桑原 知巳
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題名 (必須): (英) Utilization of titanium oxide-like compound as an inorganic phosphate adsorbent for the control of serum phosphate level in chronic renal failure.  (日)    [継承]
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要約 (任意): (英) Hyperphosphatemia adversely affects the prognosis of patients with chronic renal failure (CRF). We synthesized a titanium oxide-like compound (TAP) as a phosphate adsorbent for treatment of hyperphosphatemia in CFR patients. We evaluated the ability of TAP to adsorb inorganic phosphate in vitro and in vivo. TAP was shown to contain sulfate and hydroxyl groups by thermal analysis, which probably involved in phosphate adsorption through an ionic exchange mechanism. TAP constantly adsorbed phosphate (66.20-72.84 mg/g TAP) over a wide pH range (1.22-7.27) in vitro. To evaluate the phosphate binding potential of TAP in vivo, adenine-induced CRF rats were fed AIN-76 diet containing 3% TAP, 10% TAP, 3% sevelamer hydrochloride (clinical phosphate adsorbent), or 3% calcium carbonate, and serum levels of phosphate and calcium and urinary phosphate were compared with those in untreated CRF rats. Orally administered TAP showed the inhibitory effect on serum phosphate level in adenine-induced CRF rats, which was equivalent to that of sevelamer hydrochloride. These results indicate that TAP is a useful alternative phosphate-binder with fewer side effects than sevelamer hydrochloride and calcium carbonate.  (日)    [継承]
キーワード (推奨): 1.吸着 (adsorption) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Disease Models, Animal (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5.高リン血症 (hyperphosphatemia) [継承]
6. (英) Kidney Failure, Chronic (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Phosphates (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Rats, Sprague-Dawley (日) (読) [継承]
11.チタン (titanium) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 275 283 [継承]
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年月日 (必須): 西暦 2010年 8月 初日 (平成 22年 8月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/80021262346/ [継承]
DOI (任意): 10.2152/jmi.57.275    (→Scopusで検索) [継承]
PMID (任意): 20847528    (→Scopusで検索) [継承]
NAID (任意): 80021262346 [継承]
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機関リポジトリ : 79178 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhiko Tamagawa, Haruyuki Nakayama, Shin Wakimoto, Minoru Ichimura and Tomomi Kuwahara : Utilization of titanium oxide-like compound as an inorganic phosphate adsorbent for the control of serum phosphate level in chronic renal failure., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 275-283, 2010.
欧文冊子 ● Kazuhiko Tamagawa, Haruyuki Nakayama, Shin Wakimoto, Minoru Ichimura and Tomomi Kuwahara : Utilization of titanium oxide-like compound as an inorganic phosphate adsorbent for the control of serum phosphate level in chronic renal failure., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 275-283, 2010.

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