| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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| 2. | (英) Taki M. Masako (日) (読)
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| 3. | 能勢 歩美 ([徳島大学.病院.診療科.放射線科])
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| 4. | 久保 均
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| 5. | 森 健治 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.子どもの保健・看護学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
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| 6. | 西谷 弘
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| 7. | (英) Matsuda Tsuyoshi (日) (読)
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| ○題名 (必須): | □ | (英) Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument. (日)
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| ○要約 (任意): | □ | (英) Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. (日)
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| ○キーワード (推奨): | 1. | (英) Analysis of Variance (日) (読)
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| 2. | (英) Aspartic Acid (日) (読)
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| 3. | (英) Autistic Disorder (日) (読)
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| 4. | (英) Child (日) (読)
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| 5. | (英) Child, Preschool (日) (読)
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| 6. | (英) Corpus Striatum (日) (読)
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| 7. | (英) Frontal Lobe (日) (読)
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| 8. | (英) Glutamic Acid (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Magnetic Resonance Spectroscopy (日) (読)
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| 11. | (英) gamma-Aminobutyric Acid (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Autism and Developmental Disorders ([Springer-Verlag])
(pISSN: 0162-3257, eISSN: 1573-3432)
| ○ISSN (任意): | □ | 1573-3432
ISSN: 0162-3257
(pISSN: 0162-3257, eISSN: 1573-3432) Title: Journal of autism and developmental disordersTitle(ISO): J Autism Dev DisordSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 447 454
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 4月 初日 (平成 23年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10803-010-1065-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 20652388 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8509, Japan. masafumi@medsci.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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