| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 内藤 毅
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Shiota H (日) (読)
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| 3. | (英) Mimura Y (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Side effects in the treatment of herpetic keratitis. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Various side effects due to antiherpetic drugs observed in the last ten years in our department were studied. A total of 132 patients were treated with 5-iodo-2'-deoxyuridine (IDU), 69 with trifluorothymidine (F3T), 58 with acyclovir (ACV) and 33 with adenine arabinoside (ara-A). Patch tests were routinely done when patients exhibited contact dermatitis. Of the patients treated with IDU, 3 (2.3%) showed contact dermatitis, 2 (1.5%) follicular conjunctivitis and 1 (0.8%) punctate keratopathy. Of the patients treated with F3T, 7 (10.1%) exhibited contact dermatitis and 1 (1.4%) follicular conjunctivitis. In the group treated with ACV, 2 (3.4%) patients showed punctate keratopathy. The patients who received ara-A did not show any side effects. We found that F3T caused contact dermatitis more frequently in Japanese people than Europeans. These side effects were resolved by switching to another anti-herpetic drug without the occurrence of cross-allergy. Therefore, switching to another drug is strongly recommended when patients exhibit side effects in the treatment of herpetic keratitis. Other complications were allergy to atropine and to drug preservative. (日)
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| ○キーワード (推奨): | 1. | (英) Acyclovir (日) (読)
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| 2. | (英) Conjunctivitis (日) (読)
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| 3. | (英) Corneal Diseases (日) (読)
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| 4. | (英) Dermatitis, Contact (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Idoxuridine (日) (読)
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| 7. | (英) Keratitis, Dendritic (日) (読)
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| 8. | (英) Thymidine (日) (読)
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| 9. | (英) Trifluridine (日) (読)
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| 10. | (英) Vidarabine (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Current Eye Research (Informa Healthcare)
(pISSN: 0271-3683, eISSN: 1460-2202)
| ○ISSN (任意): | □ | 0271-3683
ISSN: 0271-3683
(pISSN: 0271-3683, eISSN: 1460-2202) Title: Current eye researchTitle(ISO): Curr Eye ResPublisher: Taylor & Francis (NLM Catalog)
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(CrossRef)
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| ○巻 (必須): | □ | 6
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 237 239
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1987年 1月 初日 (昭和 62年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 3103984 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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