| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 内藤 毅
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| 2. | (英) Irie Hiroshi (日) (読)
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| 3. | (英) Tsujimoto Kazuko (日) (読)
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| 4. | (英) Ikeda Keiko (日) (読)
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| 5. | (英) Arakawa Tsutomu (日) (読)
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| 6. | (英) Koyama Hajime A (日) (読)
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| ○題名 (必須): | □ | (英) Antiviral effect of arginine against herpes simplex virus type 1. (日)
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| ○要約 (任意): | □ | (英) We investigated the effects of arginine on the multiplication of herpes simplex virus type 1 (HSV-1) and the potential of arginine as an antiherpetic agent. Arginine suppressed the growth of HSV-1 concentration-dependently. Inhibition of HSV-1 by arginine leveled off at 50-60 mM, although the higher concentration was not suitable as an antiviral agent due to cytotoxicity. 'Time of addition' experiments revealed that arginine was particularly effective when added within 6 h post-infection (h p.i.), suggesting that the reagent sensitive step is in the early stages of the infection. A one-step growth curve of HSV-1 in the presence of 30 mM arginine revealed that: i) the latent period was significantly extended, ii) the rate of formation of progeny infectious virus decreased and iii) the final yield of progeny virus decreased to 1%. The addition of arginine at 8 h p.i., after the completion of viral DNA replication in the virus multiplication, allowed the normal formation of progeny virus in the subsequent 4 h, confirming that arginine does not directly interfere with the formation of progeny infectious virus. In addition, arginine also inhibits several RNA viruses. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antiviral Agents (日) (読)
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| 3. | (英) Arginine (日) (読)
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| 4. | (英) Cell Line (日) (読)
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| 5. | (英) Cell Line, Tumor (日) (読)
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| 6. | (英) Cercopithecus aethiops (日) (読)
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| 7. | (英) Dose-Response Relationship, Drug (日) (読)
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| 8. | (英) Herpesvirus 1, Human (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Time Factors (日) (読)
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| 11. | (英) Vero Cells (日) (読)
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| 12. | (英) Virus Replication (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Medicine (D.A. Spandidos)
(pISSN: 1107-3756, eISSN: 1791-244X)
| ○ISSN (任意): | □ | 1107-3756
ISSN: 1107-3756
(pISSN: 1107-3756, eISSN: 1791-244X) Title: International journal of molecular medicineTitle(ISO): Int J Mol MedPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 495 499
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 4月 初日 (平成 21年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/ijmm_00000156 (→Scopusで検索)
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| ○PMID (任意): | □ | 19288025 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. naito@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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