| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Juan Xiong (日) (読)
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| 2. | 柏田 良樹
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| 3. | (英) Chin-Ho Chen (日) (読)
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| 4. | (英) Keduo Qian (日) (読)
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| 5. | (英) Susan L. Morris-Natschke (日) (読)
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| 6. | (英) Kuo-Hsiung Lee (日) (読)
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| 7. | 高石 喜久
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| ○題名 (必須): | □ | (英) Conjugates of Betulin Derivatives with AZT as Potent Anti-HIV Agents. (日)
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| ○要約 (任意): | □ | (英) Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49-53, 55, 56, 59, and 60) exhibited potent anti-HIV activity at the submicromolar level, with EC(50) values ranging from 0.040 to 0.098muM in HIV-1(NL4-3) infected MT-4 cells. These compounds were equipotent or more potent than 3-O-(3',3'-dimethylsuccinyl)betulinic acid (2), which is currently in Phase IIb anti-AIDS clinical trial. (日)
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| ○キーワード (推奨): | 1. | (英) Anti-HIV Agents (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) Cell Line (日) (読)
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| 4. | (英) HIV-1 (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Triterpenes (日) (読)
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| 7. | (英) Zidovudine (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioorganic & Medicinal Chemistry ([Elsevier Science])
(pISSN: 0968-0896, eISSN: 1464-3391)
| ○ISSN (任意): | □ | 1464-3391
ISSN: 0968-0896
(pISSN: 0968-0896, eISSN: 1464-3391) Title: Bioorganic & medicinal chemistryTitle(ISO): Bioorg Med ChemPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 17
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| ○頁 (必須): | □ | 6451 6469
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 9月 初日 (平成 22年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bmc.2010.06.092 (→Scopusで検索)
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| ○PMID (任意): | □ | 20673723 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-77955982012
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima 770-8505, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) OtherID: NIHMS221547 (日)
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| 6. | (英) OtherID: PMC3016297 (日)
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