| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Juan Xiong (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Masatoshi Taniguchi (日) (読)
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| 3. | 柏田 良樹
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| 4. | (英) Michiko Sekiya (日) (読)
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| 5. | (英) Takashi Yamagishi (日) (読)
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| 6. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Papyriferic Acid Derivatives as Reversal Agents of Multidrug Resistance in Cancer Cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Forty-one derivatives of papyriferic acid were prepared based on our previous finding that methyl papyriferate (3) showed potent reversing effect on cytotoxicity of colchicine against multidrug resistance (MDR) human cancer cells (KB-C2), and evaluated for their cytotoxicity and effect on reversing P-gp-mediated MDR against KB-C2 cells. 3-O-(Morpholino-beta-oxopropanoyl)-12beta-acetoxy-3alpha,25-dihydroxy-(20S,24R)-epoxydammarane (37) significantly increased the sensitivity of colchicine against KB-C2 cells by 185-fold at 5microg/mL (7.4microM), and the cytotoxicity of colchicine was recovered to nearly that of sensitive (KB) cells. The other several new amide derivatives also exhibited potent reversal activity comparable to or more potent than methyl papyriferate and verapamil. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents (日) (読)
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| 2. | (英) Cell Line, Tumor (日) (読)
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| 3. | (英) Drug Resistance, Multiple (日) (読)
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| 4. | (英) Drug Resistance, Neoplasm (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Malonates (日) (読)
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| 7. | (英) Morpholines (日) (読)
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| 8. | (英) P-Glycoprotein (日) (読)
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| 9. | (英) Triterpenes (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioorganic & Medicinal Chemistry ([Elsevier Science])
(pISSN: 0968-0896, eISSN: 1464-3391)
| ○ISSN (任意): | □ | 1464-3391
ISSN: 0968-0896
(pISSN: 0968-0896, eISSN: 1464-3391) Title: Bioorganic & medicinal chemistryTitle(ISO): Bioorg Med ChemPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 2964 2975
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 4月 初日 (平成 22年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bmc.2010.02.046 (→Scopusで検索)
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| ○PMID (任意): | □ | 20363142 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima 770-8505, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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