『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=235291)

EID=235291EID:235291, Map:0, LastModified:2014年2月24日(月) 12:01:12, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[後東 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Matsumori Yuka (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yano Seiji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.後東 久嗣
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nakataki Emiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Wedge R. Stephen (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Ryan J. Anderson (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Sone Saburo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model.  (日)    [継承]
副題 (任意):
要約 (任意): (英) ZD6474 is a novel, orally active inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase, with some additional activity against epidermal growth factor receptor (EGFR) tyrosine kinase. The purpose of this study was to determine the potential of ZD6474 in the control of established experimental lung metastasis and pleural effusions produced by human non-small cell lung cancer (NSCLC) cells. PC14PE6 (adenocarcinoma) and H226 (squamous cell carcinoma) cells express high levels of EGFR and only PC14PE6 cells overexpress VEGF. Neither ZD6474 nor the EGFR tyrosine kinase inhibitor gefitinib inhibit proliferation of PC14PE6 or H226 cells in vitro. Both PC14PE6 and H226 cells inoculated intravenously into nude mice induced multiple lung nodules after 5-7 weeks. In addition, PC14PE6 cells produced bloody pleural effusions. Daily oral treatment with ZD6474 did not reduce the number of lung nodules produced by PC14PE6 or H226 cells, but did reduce the lung weight and the size of lung nodules. ZD6474 also inhibited the production of pleural effusions by PC14PE6 cells. Histological analyses of lung lesions revealed that ZD6474 treatment inhibited activation of VEGFR-2 and reduced tumor vascularization and tumor cell proliferation. Therapeutic effects of ZD6474 were considered likely to be due to inhibition of VEGFR-2 tyrosine kinase because gefitinib was inactive in this model. These results indicate that ZD6474, an inhibitor of VEGFR-2, may be useful in controlling the growth of established lung metastasis and pleural effusions by NSCLC.  (日)    [継承]
キーワード (推奨): 1. (英) Angiogenesis Inhibitors (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Carcinoma, Non-Small-Cell Lung (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Cell Proliferation (日) (読) [継承]
7. (英) Endothelium, Vascular (日) (読) [継承]
8. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
9. (英) Flow Cytometry (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) Lung Neoplasms (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred BALB C (日) (読) [継承]
16. (英) Neoplasm Transplantation (日) (読) [継承]
17. (英) Neoplasms, Experimental (日) (読) [継承]
18. (英) Neovascularization, Pathologic (日) (読) [継承]
19. (英) Piperidines (日) (読) [継承]
20. (英) Pleural Effusion, Malignant (日) (読) [継承]
21. (英) Quinazolines (日) (読) [継承]
22. (英) Receptor, Epidermal Growth Factor (日) (読) [継承]
23. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
24. (英) Vascular Endothelial Growth Factor Receptor-2 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Research (Cognizant Communication Corporation)
(pISSN: 0965-0407, eISSN: 1555-3906)

ISSN (任意): 0965-0407
ISSN: 0965-0407 (pISSN: 0965-0407, eISSN: 1555-3906)
Title: Oncology research
Title(ISO): Oncol Res
Publisher: Cognizant Communication Corporation
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意):
年月日 (必須): 西暦 2006年 0月 初日 (平成 18年 0月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 16783964    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000237869700002 [継承]
Scopus (任意): 2-s2.0-33645873707 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine and Molecular Therapeutics, University of Tokushima School of Medicine, Tokushima, 3-18-15 Kuramoto-cho, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuka Matsumori, Seiji Yano, Hisatsugu Goto, Emiko Nakataki, Stephen R. Wedge, Anderson J. Ryan and Saburo Sone : ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model., Oncology Research, Vol.16, No.1, 15-26, 2006.
欧文冊子 ● Yuka Matsumori, Seiji Yano, Hisatsugu Goto, Emiko Nakataki, Stephen R. Wedge, Anderson J. Ryan and Saburo Sone : ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model., Oncology Research, Vol.16, No.1, 15-26, 2006.

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