『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ledford G. Julie (日) (読)
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[継承]
2.後東 久嗣
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[継承]
3. (英) Potts N. Erin (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Degan Simone (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Chu Wei Hong (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Voelker R. Dennis (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Sunday E. Mary (日) (読)
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[継承]
8. (英) Cianciolo J. George (日) (読)
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[継承]
9. (英) Foster M. William (日) (読)
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[継承]
10. (英) Kraft Monica (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Wright Rae Jo (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The lung is constantly challenged during normal breathing by a myriad of environmental irritants and infectious insults. Pulmonary host defense mechanisms maintain homeostasis between inhibition/clearance of pathogens and regulation of inflammatory responses that could injure the airway epithelium. One component of this defense mechanism, surfactant protein-A (SP-A), exerts multifunctional roles in mediating host responses to inflammatory and infectious agents. SP-A has a bacteriostatic effect on Mycoplasma pneumoniae (Mp), which occurs by binding surface disaturated phosphatidylglycerols. SP-A can also bind the Mp membrane protein, MPN372. In this study, we investigated the role of SP-A during acute phase pulmonary infection with Mp using mice deficient in SP-A. Biologic responses, inflammation, and cellular infiltration, were much greater in Mp infected SP-A(-/-) mice than wild-type mice. Likewise, physiologic responses (airway hyperresponsiveness and lung compliance) to Mp infection were more severely affected in SP-A(-/-) mice. Both Mp-induced biologic and physiologic changes were attenuated by pharmacologic inhibition of TNF-alpha. Our findings demonstrate that SP-A is vital to preserving lung homeostasis and host defense to this clinically relevant strain of Mp by curtailing inflammatory cell recruitment and limiting an overzealous TNF-alpha response.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bronchoalveolar Lavage (日) (読) [継承]
3. (英) Homeostasis (日) (読) [継承]
4. (英) Male (日) (読) [継承]
5. (英) Mice (日) (読) [継承]
6. (英) Mice, Inbred C57BL (日) (読) [継承]
7. (英) Mice, Knockout (日) (読) [継承]
8. (英) Mycoplasma pneumoniae (日) (読) [継承]
9. (英) Pneumonia, Mycoplasma (日) (読) [継承]
10. (英) Pulmonary Surfactant-Associated Protein A (日) (読) [継承]
11. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 182 [継承]
(必須): 12 [継承]
(必須): 7818 7827 [継承]
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年月日 (必須): 西暦 2009年 6月 15日 (平成 21年 6月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0900452    (→Scopusで検索) [継承]
PMID (任意): 19494306    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● Julie G. Ledford, Hisatsugu Goto, Erin N. Potts, Simone Degan, Hong Wei Chu, Dennis R. Voelker, Mary E. Sunday, George J. Cianciolo, William M. Foster, Monica Kraft and Jo Rae Wright : SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice., The Journal of Immunology, Vol.182, No.12, 7818-7827, 2009.
欧文冊子 ● Julie G. Ledford, Hisatsugu Goto, Erin N. Potts, Simone Degan, Hong Wei Chu, Dennis R. Voelker, Mary E. Sunday, George J. Cianciolo, William M. Foster, Monica Kraft and Jo Rae Wright : SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice., The Journal of Immunology, Vol.182, No.12, 7818-7827, 2009.

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