『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=234766EID:234766, Map:0, LastModified:2012年9月20日(木) 16:05:54, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔分子生理学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Purwanti, Nunuk (日) Purwanti, Nunuk (読) プルワンティ ヌヌク
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[継承]
2. (英) Karabasil, Ratko, Mileva (日) Karabasil, Ratko, Mileva (読)
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3. (英) Matsuo, Shinsuke (日) 松尾 真介 (読) まつお しんすけ
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4.陳 剛
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5.フルジャフ ジャフラン
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6. (英) Azlina, Ahmad (日) Azlina, Ahmad (読)
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7.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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8.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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9.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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10.細井 和雄
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題名 (必須): (英) Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct  (日)    [継承]
副題 (任意):
要約 (任意): (英) To examine the very initial step that takes place immediately after tissue injury and is linked to tissue regeneration, we employed the submandibular gland (SMG), which was injured by ligation of its main excretory duct (MED). Ligation of the MED of the SMG in mice induced the expression of Sca-1, a protein marker of hematopoietic stem cells. In the normal gland, a low level of Sca-1 was expressed, which was localized predominantly in the excretory duct cells. At 1 day after ligation, Sca-1 expression increased prominently in almost all of cells in the duct system, but not in the acinar cells. The level of Sca-1 mRNA had begun to increase at 6 h after ligation and continuously rose thereafter until it reached a plateau, which occurred ∼12 h after ligation. STAT3 phosphorylated at its tyrosine-705 (p-STAT3) in the ligated gland increased immediately after ligation, and it was localized in the nuclei of all duct cells. The results of an EMSA revealed the specific binding of a nuclear extract to the sequence of the γ-interferon activation site (GAS) present in the Sca-1 promoter and confirmed that such binding increased after ligation. Thus the present study suggests that STAT3, having been phosphorylated following MED ligation, was transferred to the nucleus, where it bound to the GAS element in the promoter of Sca-1 gene, resulting in promotion of Sca-1 gene expression. Actual prevention of STAT3 phosphorylation reduced the ligation-induced Sca-1 elevation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, Ly (日) (読) [継承]
3. (英) Ligation (日) (読) [継承]
4. (英) Membrane Proteins (日) (読) [継承]
5. (英) Mice (日) (読) [継承]
6. (英) Phosphorylation (日) (読) [継承]
7. (英) Promoter Regions, Genetic (日) (読) [継承]
8. (英) STAT3 Transcription Factor (日) (読) [継承]
9. (英) Salivary Ducts (日) (読) [継承]
10. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): アメリカ生理学会 [継承]
誌名 (必須): American Journal of Physiology, Gastrointestinal and Liver Physiology ([アメリカ生理学会])
(pISSN: 0193-1857, eISSN: 1522-1547)

ISSN (任意): 1522-1547
ISSN: 0193-1857 (pISSN: 0193-1857, eISSN: 1522-1547)
Title: American journal of physiology. Gastrointestinal and liver physiology
Title(ISO): Am J Physiol Gastrointest Liver Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 301 [継承]
(必須): 5 [継承]
(必須): G814 G824 [継承]
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年月日 (必須): 西暦 2011年 12月 初日 (平成 23年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1152/ajpgi.00408.2010    (→Scopusで検索) [継承]
PMID (任意): 21868636    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima-shi, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Nunuk Purwanti, Mileva Ratko Karabasil, Shinsuke Matsuo, Gang Chen, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi : Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.301, No.5, G814-G824, 2011.
欧文冊子 ● Nunuk Purwanti, Mileva Ratko Karabasil, Shinsuke Matsuo, Gang Chen, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi : Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.301, No.5, G814-G824, 2011.

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