『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 徳島大学以外での国際共著 (徳島大学以外での複数の国の研究機関による共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Song Sungwon (日) (読)
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[継承]
2. (英) Chew Claude (日) (読)
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[継承]
3. (英) Dale M. Benjamin (日) (読)
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[継承]
4. (英) Traum Daniel (日) (読)
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[継承]
5. (英) Peacock James (日) (読)
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[継承]
6.山﨑 哲男 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品病態生化学])
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学籍番号 (推奨):
[継承]
7. (英) Clynes Raphael (日) (読)
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[継承]
8. (英) Kurosaki Tomohiro (日) (読)
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[継承]
9. (英) Greenberg Steven (日) (読)
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[継承]
題名 (必須): (英) A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Macrophages are innate immune cells that play key roles in regulation of the immune response and in tissue injury and repair. In response to specific innate immune stimuli, macrophages may exhibit signs of endoplasmic reticulum (ER) stress and progress to apoptosis. Factors that regulate macrophage survival under these conditions are poorly understood. In this study, we identified B cell adapter protein (BCAP), a p85 PI3K-binding adapter protein, in promoting survival in response to the combined challenge of LPS and ER stress. BCAP was unique among nine PI3K adapter proteins in being induced >10-fold in response to LPS. LPS-stimulated macrophages incubated with thapsigargin, a sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor that induces ER stress, underwent caspase-3 activation and apoptosis. Macrophages from BCAP(-/-) mice exhibited increased apoptosis in response to these stimuli. BCAP-deficient macrophages demonstrated decreased activation of Akt, but not ERK, and, unlike BCAP-deficient B cells, expressed normal amounts of the NF-B subunits, c-Rel and RelA. Retroviral transduction of BCAP-deficient macrophages with wild-type BCAP, but not a Y4F BCAP mutant defective in binding the SH2 domain of p85 PI3K, reversed the proapoptotic phenotype observed in BCAP-deficient macrophages. We conclude that BCAP is a nonredundant PI3K adapter protein in macrophages that is required for maximal cell survival in response to ER stress. We suggest that as macrophages engage their pathogenic targets, innate immune receptors trigger increased expression of BCAP, which endows them with the capacity to withstand further challenges from ongoing cellular insults, such as ER stress.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 187 [継承]
(必須): 2 [継承]
(必須): 619 625 [継承]
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年月日 (必須): 西暦 2011年 6月 17日 (平成 23年 6月 17日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0903425    (→Scopusで検索) [継承]
PMID (任意): 21685326    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Program in Biotechnology, Columbia University, New York, NY 10032;  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Sungwon Song, Claude Chew, Benjamin M. Dale, Daniel Traum, James Peacock, Tetsuo Yamazaki, Raphael Clynes, Tomohiro Kurosaki and Steven Greenberg : A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress., The Journal of Immunology, Vol.187, No.2, 619-625, 2011.
欧文冊子 ● Sungwon Song, Claude Chew, Benjamin M. Dale, Daniel Traum, James Peacock, Tetsuo Yamazaki, Raphael Clynes, Tomohiro Kurosaki and Steven Greenberg : A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress., The Journal of Immunology, Vol.187, No.2, 619-625, 2011.

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