| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Okamoto Masakazu (日) (読)
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| 2. | (英) Matsuda Hiroyuki (日) (読)
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| 3. | (英) Joetham Anthony (日) (読)
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| 4. | (英) Lucas J. Joseph (日) (読)
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| 5. | (英) Domenico Joanne (日) (読)
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| 6. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 7. | (英) Takeda Katsuyuki (日) (読)
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| 8. | (英) Gelfand W. Erwin (日) (読)
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| ○題名 (必須): | □ | (英) Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. (日)
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| ○要約 (任意): | □ | (英) Jagged1, a Notch ligand, and Notch have been implicated in Th2 differentiation, but their role in initiating IL-4 production and Th2 differentiation in vivo and the development of allergic airway responses has not been defined. In this study, we show that Jagged1 is up-regulated on bone marrow-derived dendritic cells (BMDCs) pulsed with allergen and that the transfer of these BMDCs before allergen challenge induces airway hyperresponsiveness (AHR) and eosinophilic airway inflammation. Treatment of CD4(+) T cells with a gamma-secretase inhibitor (GSI), which inhibits Notch signaling, resulted in decreased cytokine production when the cells were cocultured with allergen-pulsed, Jagged1-expressing BMDCs and, after the transfer of allergen-pulsed BMDCs, IL-4-deficient (IL-4(-/-)) recipients of GSI-treated naive CD4(+) T cells developed lower levels of AHR, reduced numbers of eosinophils, and lower Th2 cytokine levels when challenged with allergen. In vivo treatment of wild-type mice with Jagged1-Fc enhanced AHR and airway inflammation, whereas the transfer of BMDC transfected with Jagged1 small interfering RNA (siRNA) cells into WT or IL-4(-/-) mice before transfer of CD4(+) T cells resulted in decreased AHR, inflammation, and Th2 cytokines, indicating the critical role for Jagged1 expression on APCs. These data identify the essential role of the interactions between Notch on CD4(+) T cells and Jagged1 on APCs in the initiation of IL-4 production and Th2 differentiation for the development of AHR and allergic airway inflammation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Bronchial Hyperreactivity (日) (読)
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| 3. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 4. | (英) Calcium-Binding Proteins (日) (読)
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| 5. | (英) Cells, Cultured (日) (読)
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| 6. | (英) Coculture Techniques (日) (読)
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| 7. | (英) Dendritic Cells (日) (読)
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| 8. | (英) Eosinophilia (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Inflammation Mediators (日) (読)
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| 11. | (英) Intercellular Signaling Peptides and Proteins (日) (読)
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| 12. | (英) Interleukin-4 (日) (読)
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| 13. | (英) Lung (日) (読)
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| 14. | (英) Male (日) (読)
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| 15. | (英) Membrane Proteins (日) (読)
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| 16. | (英) Mice (日) (読)
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| 17. | (英) Mice, Inbred C57BL (日) (読)
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| 18. | (英) Mice, Knockout (日) (読)
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| 19. | (英) Ovalbumin (日) (読)
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| 20. | (英) Receptors, Notch (日) (読)
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| 21. | (英) Th2 Cells (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 1550-6606
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 183
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 2995 3003
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 8月 10日 (平成 21年 8月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.4049/jimmunol.0900692 (→Scopusで検索)
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| ○PMID (任意): | □ | 19667086 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000269391400016
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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