『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物反応工学講座 [継承]
著者 (必須): 1. (英) Kitamura Kunio (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Miura Hirohito (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Miyagawa-Tomita Sachiko (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Yanazawa Masako (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Katoh-Fukui Yuko (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Suzuki Rika (日) (読)
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学籍番号 (推奨):
[継承]
7.大内 淑代
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[継承]
8. (英) Suehiro Atuko (日) (読)
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[継承]
9. (英) Motegi Yoshiko (日) (読)
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[継承]
10. (英) Nakahara Yoko (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Kondo Shunzo (日) (読)
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[継承]
12. (英) Yokoyama Minesuke (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pitx2, a bicoid-related homeobox gene, is involved in Rieger's syndrome and the left-right (L-R) asymmetrical pattern formation in body plan. In order to define the genomic structure and roles of Pitx2, we analyzed the genomic structure and generated Pitx2-deficient mice with the lacZ gene in the homeobox-containing exon of Pitx2. We were able to show that among three isoforms of Pitx2, Pitx2c shows asymmetrical expression whereas Pitx2a, Pitx2b and Pitx2c show symmetrical expression. In Pitx2(-)(/)(-) embryos there was an increase in mesodermal cells in the distal end of the left lateral body wall and an amnion continuous with the lateral body wall thickened in its mesodermal layer. These changes resulted in a failure of ventral body wall closure. In lung and heart in which Pitx2 is expressed asymmetrically, right pulmonary isomerism, atrioventricular canals with prominent swelling, and juxtaposition of the atrium were detected. The hearts failed to develop tricuspid and mitral valves and a common atrioventricular valve forms. Further, dysgenesis of the Pitx2(-)(/)(-) extraocular muscle and thickening of the mesothelial layer of cornea were observed in the ocular system where Pitx2 is expressed symmetrically, and these resulted in enophthalmos. The present study shows that Pitx2 expressed in various sites participates in morphogenesis through three types of actions: the involvement of asymmetric Pitx2 expression in the entire morphogenetic process of L-R asymmetric organs; the involvement of asymmetric Pitx2 expression in the regional morphogenesis of asymmetric organs; and finally the involvement of symmetric Pitx2 expression in the regional morphogenesis of symmetric organs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.角膜 (cornea) [継承]
3. (英) Epithelium (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5.遺伝子発現 (gene expression) [継承]
6.心臓 (heart) [継承]
7. (英) Heart Defects, Congenital (日) (読) [継承]
8. (英) Homeodomain Proteins (日) (読) [継承]
9. (英) Lung (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mesoderm (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Nuclear Proteins (日) (読) [継承]
15. (英) Paired Box Transcription Factors (日) (読) [継承]
16. (英) Protein Isoforms (日) (読) [継承]
17. (英) Syndrome (日) (読) [継承]
18. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨): The Company of Biologists Limited [継承]
誌名 (必須): Development ([The Company of Biologists Limited])
(pISSN: 0950-1991, eISSN: 1477-9129)

ISSN (任意): 0950-1991
ISSN: 0950-1991 (pISSN: 0950-1991, eISSN: 1477-9129)
Title: Development (Cambridge, England)
Title(ISO): Development
Publisher: Company of Biologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 126 [継承]
(必須): 24 [継承]
(必須): 5749 5758 [継承]
都市 (任意):
年月日 (必須): 西暦 1999年 12月 1日 (平成 11年 12月 1日) [継承]
URL (任意): http://dev.biologists.org/cgi/content/abstract/126/24/5749 [継承]
DOI (任意):
PMID (任意): 10572050    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-0033387975 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kunio Kitamura, Hirohito Miura, Sachiko Miyagawa-Tomita, Masako Yanazawa, Yuko Katoh-Fukui, Rika Suzuki, Hideyo Ohuchi, Atuko Suehiro, Yoshiko Motegi, Yoko Nakahara, Shunzo Kondo and Minesuke Yokoyama : Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism., Development, Vol.126, No.24, 5749-5758, 1999.
欧文冊子 ● Kunio Kitamura, Hirohito Miura, Sachiko Miyagawa-Tomita, Masako Yanazawa, Yuko Katoh-Fukui, Rika Suzuki, Hideyo Ohuchi, Atuko Suehiro, Yoshiko Motegi, Yoko Nakahara, Shunzo Kondo and Minesuke Yokoyama : Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism., Development, Vol.126, No.24, 5749-5758, 1999.

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