『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=233112EID:233112, Map:0, LastModified:2015年3月20日(金) 14:23:16, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[瀬川 博子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ishiguro Mariko (日) (読)
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2.山本 浩範
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3. (英) Masuda Masashi (日) (読)
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[継承]
4. (英) Kozai Mina (日) (読)
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[継承]
5. (英) Takei Yuichiro (日) (読)
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[継承]
6. (英) Tanaka Sarasa (日) (読)
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[継承]
7. (英) Sato Tadatoshi (日) (読)
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[継承]
8.瀬川 博子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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9.竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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10.新井 英一
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11.宮本 賢一
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12.武田 英二
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題名 (必須): (英) Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The type IIa renal sodium-dependent phosphate (Na/Pi) co-transporter Npt2a is implicated in the control of serum phosphate levels. It has been demonstrated previously that renal Npt2a protein and its mRNA expression are both up-regulated by the thyroid hormone T3 (3,3',5-tri-iodothyronine) in rats. However, it has never been established whether the induction was mediated by a direct effect of thyroid hormones on the Npt2a promoter. To address the role of Npt2a in T3-dependent regulation of phosphate homoeostasis and to identify the molecular mechanisms by which thyroid hormones modulate Npt2a gene expression, mice were rendered pharmacologically hypo- and hyper-thyroid. Hypothyroid mice showed low levels of serum phosphate and a marked decrease in renal Npt2a protein abundance. Importantly, we also showed that Npt2a-deficient mice had impaired serum phosphate responsiveness to T3 compared with wild-type mice. Promoter analysis with a luciferase assay revealed that the transcriptional activity of a reporter gene containing the Npt2a promoter and intron 1 was dependent upon TRs (thyroid hormone receptors) and specifically increased by T3 in renal cells. Deletion analysis and EMSAs (electrophoretic mobility-shift assays) determined that there were unique TREs (thyroid-hormone-responsive elements) within intron 1 of the Npt2a gene. These results suggest that Npt2a plays a critical role as a T3-target gene, to control phosphate homoeostasis, and that T3 transcriptionally activates the Npt2a gene via TRs in a renal cell-specific manner.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) COS Cells (日) (読) [継承]
3. (英) Cercopithecus aethiops (日) (読) [継承]
4. (英) Dogs (日) (読) [継承]
5. (英) Electrophoretic Mobility Shift Assay (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Hela Cells (日) (読) [継承]
9.生体恒常性 (homeostasis/->キーワード[ホメオスタシス]) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Kidney (日) (読) [継承]
12. (英) Luciferases (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Knockout (日) (読) [継承]
16. (英) Phosphates (日) (読) [継承]
17. (英) Promoter Regions, Genetic (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Receptors, Thyroid Hormone (日) (読) [継承]
20. (英) Response Elements (日) (読) [継承]
21. (英) Sodium-Phosphate Cotransporter Proteins, Type IIa (日) (読) [継承]
22. (英) Transcription, Genetic (日) (読) [継承]
23. (英) Transcriptional Activation (日) (読) [継承]
24. (英) Triiodothyronine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 1470-8728
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 427 [継承]
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(必須): 161 169 [継承]
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年月日 (必須): 西暦 2010年 3月 15日 (平成 22年 3月 15日) [継承]
URL (任意):
DOI (任意): 10.1042/BJ20090671    (→Scopusで検索) [継承]
PMID (任意): 20088828    (→Scopusで検索) [継承]
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WOS (任意): 000276583300016 [継承]
Scopus (任意): 2-s2.0-77950874525 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto-Cho 3-18-15, Tokushima City 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mariko Ishiguro, Hironori Yamamoto, Masashi Masuda, Mina Kozai, Yuichiro Takei, Sarasa Tanaka, Tadatoshi Sato, Hiroko Segawa, Yutaka Taketani, Hidekazu Arai, Ken-ichi Miyamoto and Eiji Takeda : Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene., The Biochemical Journal, Vol.427, No.1, 161-169, 2010.
欧文冊子 ● Mariko Ishiguro, Hironori Yamamoto, Masashi Masuda, Mina Kozai, Yuichiro Takei, Sarasa Tanaka, Tadatoshi Sato, Hiroko Segawa, Yutaka Taketani, Hidekazu Arai, Ken-ichi Miyamoto and Eiji Takeda : Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene., The Biochemical Journal, Vol.427, No.1, 161-169, 2010.

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