| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域])
| [継承] |
| ○著者 (必須): | 1. | 谷口 貴子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 木戸 慎介
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 山内 英美子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 松本 俊夫
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 谷口 寿章
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Induction of endosomal/lysosomal pathways in differentiating osteoblasts as revealed by combined proteomic and transcriptomic analyses. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We have analyzed proteome changes associated with bone-forming osteoblast differentiation by quantitative differential proteomic and transcriptomic analyses using in vitro differentiation model. Sixty nine proteins were found up-regulated (>2-fold) and 18 were down-regulated (<0.5-fold) at protein level. The mRNA levels of these proteins were then analyzed by quantitative real-time PCR combined with clustering analysis. The most prominent cluster with increased protein and mRNA levels contains endosomal and lysosomal proteins, demonstrating the drastic induction of degradative endosomal/lysosomal pathways in osteoblasts. Osteoblasts, therefore, are involved not only in the synthesis but also in the turnover of the extracellular matrix proteins such as collagens. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | 細胞分化 (cell differentiation)
| [継承] |
| 3. | (英) Gene Expression Profiling (日) (読)
| [継承] |
| 4. | (英) Lysosomes (日) (読)
| [継承] |
| 5. | (英) Mice (日) (読)
| [継承] |
| 6. | (英) Mice, Inbred ICR (日) (読)
| [継承] |
| 7. | (英) Osteoblasts (日) (読)
| [継承] |
| 8. | (英) Plasmids (日) (読)
| [継承] |
| 9. | プロテオーム (proteome)
| [継承] |
| 10. | プロテオミクス (proteomics)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | FEBS Letters ([Federation of European Biochemical Societies])
(pISSN: 0014-5793, eISSN: 1873-3468)
| ○ISSN (任意): | □ | 1873-3468
ISSN: 0014-5793
(pISSN: 0014-5793, eISSN: 1873-3468) Title: FEBS lettersTitle(ISO): FEBS LettSupplier: Federation of European Biochemical SocietiesPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 584
| [継承] |
| ○号 (必須): | □ | 18
| [継承] |
| ○頁 (必須): | □ | 3969 3974
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 8月 2日 (平成 22年 8月 2日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.febslet.2010.07.055 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 20682313 (→Scopusで検索)
| [継承] |
| ○NAID (任意): |
| ○WOS (任意): | □ | 000282187500023
| [継承] |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |