『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨): 博士後期課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1.Chung Le Thi Kim
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学籍番号 (推奨):
[継承]
2.保坂 利男
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[継承]
3.原田 永勝
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学籍番号 (推奨):
[継承]
4. (英) Jambaldorj Bayasgalan (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Fukunaga Keiko (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Nishiwaki Yuka (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Teshigawara Kiyoshi (日) (読)
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[継承]
8.酒井 徹 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])
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学籍番号 (推奨):
[継承]
9.中屋 豊
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10.船木 真理 ([徳島大学.病院.中央診療施設等.糖尿病対策センター])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In adipocytes and myocytes, insulin stimulation translocates glucose transporter 4 (Glut4) storage vesicles (GSVs) from their intracellular storage sites to the plasma membrane (PM) where they dock with the PM. Then, Glut4 is inserted into the PM and initiates glucose uptake into these cells. Previous studies using chemical inhibitors demonstrated that myosin II participates in fusion of GSVs and the PM and increase in the intrinsic activity of Glut4. In this study, the effect of myosin IIA on GSV trafficking was examined by knocking down myosin IIA expression. Myosin IIA knockdown decreased both glucose uptake and exposures of myc-tagged Glut4 to the cell surface in insulin-stimulated cells, but did not affect insulin signal transduction. Interestingly, myosin IIA knockdown failed to decrease insulin-dependent trafficking of Glut4 to the PM. Moreover, in myosin IIA knockdown cells, insulin-stimulated binding of GSV SNARE protein, vesicle-associated membrane protein 2 (VAMP2) to PM SNARE protein, syntaxin 4 was inhibited. These data suggest that myosin IIA plays a role in insulin-stimulated docking of GSVs to the PM in 3T3-L1 adipocytes through SNARE complex formation.  (日)    [継承]
キーワード (推奨): 1. (英) 3T3-L1 Cells (日) (読) [継承]
2. (英) Adipocytes (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cell Membrane (日) (読) [継承]
5. (英) Cytoplasmic Vesicles (日) (読) [継承]
6. (英) Gene Knockdown Techniques (日) (読) [継承]
7. (英) Glucose (日) (読) [継承]
8. (英) Glucose Transporter Type 4 (日) (読) [継承]
9. (英) Insulin (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Nonmuscle Myosin Type IIA (日) (読) [継承]
12. (英) Protein Transport (日) (読) [継承]
13. (英) SNARE Proteins (日) (読) [継承]
14.情報伝達 (signal transduction/->キーワード[シグナル伝達]) [継承]
15. (英) Vesicle-Associated Membrane Protein 2 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 1090-2104
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1 [継承]
(必須): 995 999 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 12月 5日 (平成 21年 12月 5日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbrc.2009.12.004    (→Scopusで検索) [継承]
PMID (任意): 19968963    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. ngocanh@nutr.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Le Thi Kim Chung, Toshio Hosaka, Nagakatsu Harada, Bayasgalan Jambaldorj, Keiko Fukunaga, Yuka Nishiwaki, Kiyoshi Teshigawara, Tohru Sakai, Yutaka Nakaya and Makoto Funaki : Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes., Biochemical and Biophysical Research Communications, Vol.391, No.1, 995-999, 2009.
欧文冊子 ● Le Thi Kim Chung, Toshio Hosaka, Nagakatsu Harada, Bayasgalan Jambaldorj, Keiko Fukunaga, Yuka Nishiwaki, Kiyoshi Teshigawara, Tohru Sakai, Yutaka Nakaya and Makoto Funaki : Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes., Biochemical and Biophysical Research Communications, Vol.391, No.1, 995-999, 2009.

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