『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=232288EID:232288, Map:0, LastModified:2012年10月5日(金) 22:24:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[中西 正], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨):
著者 (必須): 1.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.向井 佳代
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3.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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4.平尾 功治 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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5.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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6.松尾 敬志
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題名 (必須): (英) Anti-inflammatory effect of catechin on cultured dental pulp cells affected by bacteria-derived factors  (日)    [継承]
副題 (任意):
要約 (任意): (英) Catechins (bioactive polyphenols in green tea) are known to exhibit potent anti-inflammatory properties. However, the anti-inflammatory effects of catechins on inflamed dental pulp tissue are not known. In this study, we investigated the effect of epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), the major components of green tea catechins, on the expression of pro-inflammatory cytokines and adhesion molecules in human dental pulp cells stimulated with bacteria-derived factors such as lipopolysaccharide (LPS) and peptidoglycan (PG). The expression of interleukin (IL)-6 and of IL-8 was examined using the reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assays. The expression of intercellular adhesion molecule-1 (ICAM-1) and of vascular cell adhesion molecule-1 (VCAM-1) on dental pulp cells was analyzed using flow cytometry. The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG. Increased expression of ICAM-1 and VCAM-1 on the dental pulp cells in response to bacterial components was also decreased by treatment with EGCG and ECG. These findings suggest that green tea catechins may prevent the exacerbation of pulpitis.  (日)    [継承]
キーワード (推奨): 1. (英) Anti-Inflammatory Agents (日) (読) [継承]
2. (英) Antioxidants (日) (読) [継承]
3. (英) Catechin (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Dental Pulp (日) (読) [継承]
6. (英) Escherichia coli (日) (読) [継承]
7. (英) Flow Cytometry (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
10. (英) Interleukin-6 (日) (読) [継承]
11. (英) Interleukin-8 (日) (読) [継承]
12. (英) Lipopolysaccharides (日) (読) [継承]
13. (英) Peptidoglycan (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Staphylococcus aureus (日) (読) [継承]
16. (英) Time Factors (日) (読) [継承]
17. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Journal of Oral Sciences (N.O.F - Scandinavian Division of the International Association for Dental Research)
(pISSN: 0909-8836, eISSN: 1600-0722)

ISSN (任意): 1600-0722
ISSN: 0909-8836 (pISSN: 0909-8836, eISSN: 1600-0722)
Title: European journal of oral sciences
Title(ISO): Eur. J. Oral Sci.
Supplier: Scandinavian Division of the International Association for Dental Research
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 145 150 [継承]
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年月日 (必須): 西暦 2010年 4月 初日 (平成 22年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1600-0722.2010.00714.x    (→Scopusで検索) [継承]
PMID (任意): 20487003    (→Scopusで検索) [継承]
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WOS (任意): 000275510500006 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tadashi@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tadashi Nakanishi, Kayo Mukai, Hiromichi Yumoto, Kouji Hirao, Yoshitaka Hosokawa and Takashi Matsuo : Anti-inflammatory effect of catechin on cultured dental pulp cells affected by bacteria-derived factors, European Journal of Oral Sciences, Vol.118, No.2, 145-150, 2010.
欧文冊子 ● Tadashi Nakanishi, Kayo Mukai, Hiromichi Yumoto, Kouji Hirao, Yoshitaka Hosokawa and Takashi Matsuo : Anti-inflammatory effect of catechin on cultured dental pulp cells affected by bacteria-derived factors, European Journal of Oral Sciences, Vol.118, No.2, 145-150, 2010.

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