『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=231995EID:231995, Map:0, LastModified:2012年9月25日(火) 11:26:25, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.水野 大
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2.武井 恒知
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3. (英) Fukuta Akiho (日) 福田 明穂 (読)
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4. (英) Shinahara Wakako (日) 品原 和加子 (読)
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5.高橋 悦久 ([徳島大学.先端酵素学研究所.重点研究部門])
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6.矢野 仁康
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7.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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題名 (必須): (英) Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have reported that Surfacten(®) (St), a bovine pulmonary surfactant free of antigenic c-type lectins, is a useful mucosal adjuvant for nasal vaccination. To prepare ample supplies a synthetic adjuvant that mimics St, we analyzed essential constituents of St for mucosal adjuvanticity. Intranasal inoculation of influenza virus hemagglutinin (HA) vaccine combined with St free of surfactant protein (SP)-C resulted in failure of HA vaccine delivery to dendritic cells and loss of local and systemic immune responses. Naïve bovine SP-C, synthetic human or bovine SP-C peptide reconstituted with three major St lipids restored delivery activity and local and systemic immune responses to levels similar to those of St and provided almost complete protection against lethal doses of influenza virus challenge in mice. The delivery of fluoresceinated HA vaccine to cultured dendritic cells was significantly enhanced by co-administration of St or synthetic adjuvant, and moderately stimulated the expression of MHC class II and CD86. In addition, both St and synthetic adjuvant markedly sustained HA vaccine and achieved a wide antigen distribution in murine nasal cavity. These results suggest that synthetic mucosal adjuvant reconstituted with SP-C peptide and major St lipids is useful for ample supply of the potent mucosal adjuvant as an antigen delivery vehicle for intranasal vaccination.  (日)    [継承]
キーワード (推奨): 1. (英) Adjuvants, Immunologic (日) (読) [継承]
2. (英) Administration, Intranasal (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Antigens, CD86 (日) (読) [継承]
5. (英) Biological Agents (日) (読) [継承]
6. (英) Disease Models, Animal (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Hemagglutinin Glycoproteins, Influenza Virus (日) (読) [継承]
9. (英) Histocompatibility Antigens Class II (日) (読) [継承]
10. (英) Immunity, Mucosal (日) (読) [継承]
11. (英) Influenza Vaccines (日) (読) [継承]
12. (英) Lipopeptides (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred BALB C (日) (読) [継承]
15. (英) Orthomyxoviridae Infections (日) (読) [継承]
16. (英) Peptides, Cyclic (日) (読) [継承]
17. (英) Rodent Diseases (日) (読) [継承]
18. (英) Vaccines, Subunit (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Vaccine (The Edward Jenner Society/The International Society for Vaccines/日本ワクチン学会)
(pISSN: 0264-410X, eISSN: 1873-2518)

ISSN (任意): 1873-2518
ISSN: 0264-410X (pISSN: 0264-410X, eISSN: 1873-2518)
Title: Vaccine
Title(ISO): Vaccine
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 29 [継承]
(必須): 33 [継承]
(必須): 5368 5378 [継承]
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年月日 (必須): 西暦 2011年 6月 12日 (平成 23年 6月 12日) [継承]
URL (任意):
DOI (任意): 10.1016/j.vaccine.2011.05.090    (→Scopusで検索) [継承]
PMID (任意): 21669246    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Dai Mizuno, Tunetomo Takei, Akiho Fukuta, Wakako Shinahara, Etsuhisa Takahashi, Mihiro Yano and Hiroshi Kido : Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity, Vaccine, Vol.29, No.33, 5368-5378, 2011.
欧文冊子 ● Dai Mizuno, Tunetomo Takei, Akiho Fukuta, Wakako Shinahara, Etsuhisa Takahashi, Mihiro Yano and Hiroshi Kido : Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity, Vaccine, Vol.29, No.33, 5368-5378, 2011.

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