| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 2. | 矢野 雅司 ([徳島大学.技術支援部])
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| 3. | (英) Shinzawa Miho (日) (読)
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| 4. | (英) Shimo Yusuke (日) (読)
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| 5. | 廣田 史子
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| 6. | 西川 裕美子
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| 7. | (英) Nii Takuro (日) (読)
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| 8. | (英) Kiyonari Hiroshi (日) (読)
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| 9. | (英) Abe Takaya (日) (読)
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| 10. | (英) Uehara Hisanori (日) (読)
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| 11. | (英) Izumi Keisuke (日) (読)
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| 12. | (英) Tamada Koji (日) (読)
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| 13. | (英) Chen Lieping (日) (読)
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| 14. | (英) Penninger M. Josef (日) (読)
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| 15. | (英) Inoue Jun-ichiro (日) (読)
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| 16. | (英) Akiyama Taishin (日) (読)
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| 17. | 松本 満
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| ○題名 (必須): | □ | (英) Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (日)
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| ○要約 (任意): | □ | (英) It has recently become clear that signals mediated by members of the TNFR superfamily, including lymphotoxin-β receptor (LTβR), receptor activator for NF-κB (RANK), and CD40, play essential roles in organizing the integrity of medullary thymic epithelial cells (mTECs) required for the establishment of self-tolerance. However, details of the mechanism responsible for the unique and cooperative action of individual and multiple TNFR superfamily members during mTEC differentiation still remain enigmatic. In this study, we show that the LTβR signal upregulates expression of RANK in the thymic stroma, thereby promoting accessibility to the RANK ligand necessary for mTEC differentiation. Cooperation between the LTβR and RANK signals for optimal mTEC differentiation was underscored by the exaggerated defect of thymic organogenesis observed in mice doubly deficient for these signals. In contrast, we observed little cooperation between the LTβR and CD40 signals. Thus, the LTβR signal exhibits a novel and unique function in promoting RANK activity for mTEC organization, indicating a link between thymic organogenesis mediated by multiple cytokine signals and the control of autoimmunity. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD40 (日) (読)
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| 3. | 細胞分化 (cell differentiation)
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| 4. | (英) Embryo, Mammalian (日) (読)
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| 5. | (英) Epithelial Cells (日) (読)
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| 6. | (英) Flow Cytometry (日) (読)
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| 7. | 遺伝子発現 (gene expression)
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| 8. | (英) Gene Expression Regulation (日) (読)
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| 9. | 免疫組織化学 (immunohistochemistry)
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| 10. | (英) Lymphotoxin beta Receptor (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Mice, Knockout (日) (読)
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| 13. | (英) Organogenesis (日) (読)
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| 14. | (英) Receptor Activator of Nuclear Factor-kappa B (日) (読)
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| 15. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 16. | (英) Self Tolerance (日) (読)
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| 17. | シグナル伝達 (signal transduction)
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| 18. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 1550-6606
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 186
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 5047 5057
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| ○年月日 (必須): | □ | 西暦 2011年 3月 25日 (平成 23年 3月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.4049/jimmunol.1003533 (→Scopusで検索)
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| ○PMID (任意): | □ | 21441458 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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