『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.内田 大亮
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2.尾上 富太郎
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3. (英) Tomizuka Yoshifumi (日) (読)
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4. (英) Begum Mila Nasima (日) (読)
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5. (英) Miwa Yoshihiro (日) (読)
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6.吉田 秀夫
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7.佐藤 光信
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題名 (必須): (英) Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have previously shown that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis, but not in that of distant metastasis, in oral squamous cell carcinoma (SCC). In this study, we investigated the role of the autocrine SDF-1/CXCR4 system, with a focus on distant metastasis in oral SCC cells. The immunohistochemical staining of SDF-1 and CXCR4 using primary oral SCCs and metastatic lymph nodes showed a significantly higher number of SDF-1-positive cases among the metastatic lymph nodes than among the primary oral SCCs, which was associated with a poor survival rate among those of the former group. The forced expression of SDF-1 in B88 cells, which exhibit functional CXCR4 and lymph node metastatic potential (i.e., the autocrine SDF-1/CXCR4 system), conferred enhanced cell motility and anchorage-independent growth potential onto the cells. Orthotopic inoculation of the transfectant into nude mice was associated with an increase in the number of metastatic lymph nodes and more aggressive metastatic foci in the lymph nodes. Furthermore, the SDF-1 transfectant (i.e., the autocrine SDF-1/CXCR4 system) exhibited dramatic metastasis to the lung after i.v. inoculation, whereas the mock transfectant (i.e., the paracrine SDF-1/CXCR4 system) did not. Under the present conditions, AMD3100, a CXCR4 antagonist, significantly inhibited the lung metastasis of the SDF-1 transfectant, ameliorated body weight loss, and improved the survival rate of tumor-bearing nude mice. These results suggested that, in cases of oral SCC, the paracrine SDF-1/CXCR4 system potentiates lymph node metastasis, but distant metastasis might require the autocrine SDF-1/CXCR4 system.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Aged, 80 and over (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Autocrine Communication (日) (読) [継承]
5. (英) Carcinoma, Squamous Cell (日) (読) [継承]
6. (英) Chemokine CXCL12 (日) (読) [継承]
7. (英) Chemokines, CXC (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Heterocyclic Compounds (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Lung Neoplasms (日) (読) [継承]
12. (英) Lymphatic Metastasis (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Nude (日) (読) [継承]
16. (英) Middle Aged (日) (読) [継承]
17. (英) Mouth Neoplasms (日) (読) [継承]
18. (英) Phenotype (日) (読) [継承]
19. (英) Receptors, CXCR4 (日) (読) [継承]
20. (英) Survival Analysis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Cancer Research : MCR ([American Association for Cancer Research])
(pISSN: 1541-7786, eISSN: 1557-3125)

ISSN (任意): 1541-7786
ISSN: 1541-7786 (pISSN: 1541-7786, eISSN: 1557-3125)
Title: Molecular cancer research : MCR
Title(ISO): Mol. Cancer Res.
Publisher: American Association for Cancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 5 [継承]
(必須): 7 [継承]
(必須): 685 694 [継承]
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年月日 (必須): 西暦 2007年 7月 初日 (平成 19年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1158/1541-7786.MCR-06-0368    (→Scopusで検索) [継承]
PMID (任意): 17634424    (→Scopusで検索) [継承]
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WOS (任意): 000248200700004 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. daisuke@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Tomitaro Onoue, Yoshifumi Tomizuka, Nasima Mila Begum, Yoshihiro Miwa, Hideo Yoshida and Mitsunobu Sato : Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma., Molecular Cancer Research : MCR, Vol.5, No.7, 685-694, 2007.
欧文冊子 ● Daisuke Uchida, Tomitaro Onoue, Yoshifumi Tomizuka, Nasima Mila Begum, Yoshihiro Miwa, Hideo Yoshida and Mitsunobu Sato : Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma., Molecular Cancer Research : MCR, Vol.5, No.7, 685-694, 2007.

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