『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=229715EID:229715, Map:0, LastModified:2021年3月2日(火) 11:09:27, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Wang Di (日) Wang Di (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yuan Zhenfang (日) Yuan Zhenfang (読)
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学籍番号 (推奨):
[継承]
3. (英) Inoue Noriko (日) Inoue Noriko (読)
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学籍番号 (推奨):
[継承]
4. (英) Cho Gota (日) Cho Gota (読)
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学籍番号 (推奨):
[継承]
5.庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.石川 康子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) The mechanisms underlying diabetic xerostomia have not been clarified in relation with aquaporin-5 (AQP5) subcellular localization in salivary glands. Western blotting, real-time PCR, and immunocytochemistry were used to analyse AQP5 protein levels and mRNA expression. AQP5 protein levels were measured in the apical plasma membrane (APM) and detergent-insoluble fraction prepared from streptozotocin-diabetic rat parotid glands. Despite an increase in AQP5 mRNA, AQP5 protein levels were decreased in diabetic parotid glands compared with controls. Immunohistochemical studies indicated that AQP5, under unstimulated conditions, colocalised with flotillin-2 and GM1 with a diffuse pattern in the apical cytoplasm of acinar and duct cells in both control and diabetic rats. Ten minutes after intravenous injection of muscarinic agonist cevimeline, AQP5 was dramatically increased together with flotillin-2 and GM1 in the APM of parotid acinar and duct cells of control but not diabetic rats. Sixty minutes after injection, AQP5 was located in a diffuse pattern in the apical cytoplasm in both rats. Treatment of the parotid tissues with cevimeline for 10min increased the Triton X-100 solubility of AQP5 in control but not diabetic rats. Administration of insulin to diabetic rats tended to restore the cevimeline-induced translocation of AQP5. Lack of AQP5 translocation in the salivary gland in response to a muscarinic agonist and downregulation of AQP5 protein might lead to diabetic xerostomia. Cevimeline is useful to cure diabetic xerostomia under insulin administration.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Aquaporin 5 (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (英) Cell Membrane (日) (読) [継承]
5. (英) Cyclic GMP (日) (読) [継承]
6. (英) Cytoplasm (日) (読) [継承]
7. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
8. (英) Down-Regulation (日) (読) [継承]
9. (英) Hypoglycemic Agents (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11.インスリン (insulin) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Membrane Proteins (日) (読) [継承]
14. (英) Muscarinic Agonists (日) (読) [継承]
15.一酸化窒素 (nitric oxide) [継承]
16. (英) Parotid Gland (日) (読) [継承]
17. (英) Protein Transport (日) (読) [継承]
18. (英) Quinuclidines (日) (読) [継承]
19. (英) Rats (日) (読) [継承]
20. (英) Rats, Wistar (日) (読) [継承]
21. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
22. (英) Thiophenes (日) (読) [継承]
23. (英) Time Factors (日) (読) [継承]
24. (英) Xerostomia (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165, eISSN: 1872-8006)

ISSN (任意): 0304-4165
ISSN: 0304-4165 (pISSN: 0304-4165, eISSN: 1872-8006)
Title: Biochimica et biophysica acta. General subjects
Title(ISO): Biochim Biophys Acta Gen Subj
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1810 [継承]
(必須): 5 [継承]
(必須): 543 554 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 2月 2日 (平成 23年 2月 2日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbagen.2011.01.013    (→Scopusで検索) [継承]
PMID (任意): 21295117    (→Scopusで検索) [継承]
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WOS (任意): 000290067900007 [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Medical Pharmacology, The University of Tokushima Graduate School, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Di Wang, Zhenfang Yuan, Noriko Inoue, Gota Cho, Masayuki Shono and Yasuko Ishikawa : Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1810, No.5, 543-554, 2011.
欧文冊子 ● Di Wang, Zhenfang Yuan, Noriko Inoue, Gota Cho, Masayuki Shono and Yasuko Ishikawa : Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1810, No.5, 543-554, 2011.

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