| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 日本語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 永井 宏和
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| 2. | 髙丸 菜都美 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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| 3. | 大江 剛
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| 4. | 内田 大亮
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| 5. | 玉谷 哲也
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| 6. | 藤澤 健司
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| 7. | 岩本 誠司
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| 8. | 宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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| ○題名 (必須): | □ | (英) [Evaluation of Combination Chemotherapy with Oral S-1 Administration Followed by Docetaxel by Superselective Intra-Arterial Infusion for Patients with Oral Squamous Cell Carcinomas.] (日) 口腔扁平上皮癌に対するS-1を併用したDocetaxel超選択的動注化学療法の臨床効果に関する研究
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| ○要約 (任意): | □ | (英) The purpose of this study was to evaluate the effectiveness and adverse events of combination chemotherapy with oral S-1 administration following docetaxel(DOC)treatment by superselective intra-arterial infusion as neo-adjuvant chemotherapy (NAC)for patients with oral squamous cell carcinoma. Thirteen patients were enrolled in this study(9 men and 4 women, with a mean age of 61. 0 years). All patients were given S-1 65mg/m / 2 per day for 14 days, and DOC 40-50mg/m2 by intraarterial infusion was administered. The locoregional response evaluated 3 weeks after administration was 100%, including a 69. 2% complete response. According to Oboshi and Shimosato's classification, histological evaluation of surgical specimens revealed that 3 cases were Grade IIa, 4 cases Grade IIb, 1 case Grade IVa, and 4 cases Grade IVc. The severe side effects were neutropenia and cerebral infarction. The present study suggests that combination chemotherapy with S-1 and DOC by superselective intra-arterial infusion would be an effective and safe regimen in NAC for oral squamous cell carcinomas. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Oral (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Aged (日) (読)
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| 4. | (英) Aged, 80 and over (日) (読)
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| 5. | (英) Antineoplastic Combined Chemotherapy Protocols (日) (読)
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| 6. | (英) Carcinoma, Squamous Cell (日) (読)
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| 7. | (英) Cerebral Infarction (日) (読)
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| 8. | (英) Drug Combinations (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Infusions, Intra-Arterial (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | (英) Mouth Neoplasms (日) (読)
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| 15. | (英) Neoplasm Staging (日) (読)
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| 16. | (英) Neutropenia (日) (読)
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| 17. | (英) Oxonic Acid (日) (読)
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| 18. | (英) Taxoids (日) (読)
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| 19. | (英) Tegafur (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | 癌と化学療法 (癌と化学療法社)
(pISSN: 0385-0684)
| ○ISSN (任意): | □ | 0385-0684
ISSN: 0385-0684
(pISSN: 0385-0684) Title: Gan to kagaku ryoho. Cancer & chemotherapyTitle(ISO): Gan To Kagaku RyohoPublisher: Japanese Journal of Cancer & Chemotherapy Publishers Inc. (NLM Catalog)
(医中誌Web)
(Scopus)
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| ○巻 (必須): | □ | 38
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 777 781
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 5月 初日 (平成 23年 5月 初日)
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| ○PMID (任意): | □ | 21566436 (→Scopusで検索)
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| ○CRID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-79960998915
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Dept. of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Health Biosciences. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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