『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学]/徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.歯学系.予防歯学令和6年4月より併任)
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○学籍番号 (推奨):
[継承]
2. (英) Fujihashi Kohtaro (日) (読)
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[継承]
3. (英) Oma Keita (日) (読)
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[継承]
4. (英) Fukuyama Yoshiko (日) (読)
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○学籍番号 (推奨):
[継承]
5. (英) Hollingshead Susan K (日) (読)
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○学籍番号 (推奨):
[継承]
6. (英) Sekine Shinichi (日) (読)
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○学籍番号 (推奨):
[継承]
7. (英) Kawabata Shigetada (日) (読)
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○学籍番号 (推奨):
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8.伊藤 博夫
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○学籍番号 (推奨):
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9. (英) Briles David E (日) (読)
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○学籍番号 (推奨):
[継承]
10. (英) Oishi Kazunori (日) (読)
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[継承]
○題名 (必須): □(英) Nasal Dendritic Cell Targeting Flt3 Ligand As A Safe Adjuvant Elicits Effective Protection Against Fatal Pneumococcal Pneumonia.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) We have previously shown that pneumococcal surface protein A (PspA)-based vaccine containing DNA plasmid encoding the Flt3 ligand (FL) gene (pFL) as nasal adjuvant prevented nasal carriage of Streptococcus pneumoniae. In this study, we further investigated the safety and efficacy of this nasal vaccine for the induction of PspA-specific antibody (Ab) responses against lung infection with S. pneumoniae. C57BL/6 mice were nasally immunized with recombinant PspA/Rx1 (rPspA) plus pFL three times at weekly intervals. When dynamic translocation of pFL was initially examined, nasal pFL was taken-up by nasal dendritic cells (DCs) and epithelial cells (nECs), but not in the central nervous systems including olfactory nerve and epithelium. Of importance, nasal pFL induced FL protein synthesis with minimum levels of inflammatory cytokines in the nasal washes (NWs) and bronchoalveolar lavage fluid (BALF). NWs and BALF as well as plasma of mice given nasal rPspA plus pFL contained increased levels of rPspA-specific secretory-IgA and IgG Ab responses that are correlated with elevated numbers of CD8(+) and CD11b(+) DCs and IL-2 and IL-4 producing CD4(+) T cells in the nasopharyngeal-associated lymphoid tisses (NALT) and cervical lymph nodes (CLNs). The in vivo protection by rPspA-specific Abs was evident by reduced numbers of CFU in the lungs, airway secretions, and blood when mice were nasally challenged with Streptococcus pneumoniae WU2. Our findings show that nasal pFL is a safe and effective mucosal adjuvant for the enhancement of bacterial Ag (rPspA)-specific protective immunity through DC-induced Th2-type and IL-2 cytokine responses.  (日)    [継承]
○キーワード (推奨): 1. (英) Adjuvants, Immunologic (日) (読) [継承]
2. (英) Administration, Intranasal (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Antibodies, Bacterial (日) (読) [継承]
5. (英) Bacterial Proteins (日) (読) [継承]
6. (英) Bronchoalveolar Lavage Fluid (日) (読) [継承]
7. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
8. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
9.細胞質分裂 (cytokinesis) [継承]
10. (英) Dendritic Cells (日) (読) [継承]
11. (英) Epithelial Cells (日) (読) [継承]
12. (英) Immunoglobulin A, Secretory (日) (読) [継承]
13. (英) Immunoglobulin G (日) (読) [継承]
14. (英) Membrane Proteins (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16. (英) Mice, Inbred C57BL (日) (読) [継承]
17. (英) Nasal Cavity (日) (読) [継承]
18. (英) Nasal Mucosa (日) (読) [継承]
19. (英) Nasal Sprays (日) (読) [継承]
20. (英) Plasmids (日) (読) [継承]
21. (英) Pneumococcal Vaccines (日) (読) [継承]
22. (英) Pneumonia, Pneumococcal (日) (読) [継承]
23. (英) Recombinant Proteins (日) (読) [継承]
24. (英) Streptococcus pneumoniae (日) (読) [継承]
25. (英) Vaccines, Synthetic (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Infection and Immunity ([アメリカ微生物学会])
(pISSN: 0019-9567, eISSN: 1098-5522)

○ISSN (任意): □1098-5522
ISSN: 0019-9567 (pISSN: 0019-9567, eISSN: 1098-5522)
Title: Infection and immunity
Title(ISO): Infect Immun
Publisher: American Society for Microbiology
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □79 [継承]
○号 (必須): □7 [継承]
○頁 (必須): □2819 2828 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2011年 5月 2日 (平成 23年 5月 2日) [継承]
○URL (任意):
○DOI (任意): □10.1128/IAI.01360-10    (→Scopusで検索) [継承]
○PMID (任意): □21536790    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Affiliation: Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8504 JAPAN.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Kosuke Kataoka, Kohtaro Fujihashi, Keita Oma, Yoshiko Fukuyama, K Susan Hollingshead, Shinichi Sekine, Shigetada Kawabata, Hiro-O Ito, E David Briles and Kazunori Oishi : Nasal Dendritic Cell Targeting Flt3 Ligand As A Safe Adjuvant Elicits Effective Protection Against Fatal Pneumococcal Pneumonia., Infection and Immunity, Vol.79, No.7, 2819-2828, 2011.
欧文冊子 ● Kosuke Kataoka, Kohtaro Fujihashi, Keita Oma, Yoshiko Fukuyama, K Susan Hollingshead, Shinichi Sekine, Shigetada Kawabata, Hiro-O Ito, E David Briles and Kazunori Oishi : Nasal Dendritic Cell Targeting Flt3 Ligand As A Safe Adjuvant Elicits Effective Protection Against Fatal Pneumococcal Pneumonia., Infection and Immunity, Vol.79, No.7, 2819-2828, 2011.

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