『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.永井 宏和
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学籍番号 (推奨):
[継承]
2. (英) Terada Kunihiko (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Watanabe Go (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Ueno Yasuharu (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Aiba Namiko (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Shibuya Tomomi (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Kawagoe Masami (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Kameda Takashi (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Sato Mitsuru (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Senoo Haruki (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Sugiyama Toshihiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The liver is believed to contain stem cells that can differentiate into either hepatocytes or biliary epithelial cells. In the present study, we established a nonhepatocytic epithelial cell line from the normal livers of adult rats. The established cells, designated HSL cells, were immunoreactive against alpha-fetoprotein, but neither albumin nor cytokeratin 19. To demonstrate the differentiation potential of HSL cells in vitro, the cells were cocultured with hepatic stellate cells as a mixture or separately using insert wells. Consequently, although coculture with hepatic stellate cells rendered HSL cells able to produce albumin, the mixed coculture system mimicking the hepatic environment elicited this phenomenon more effectively than the separated coculture system. In conclusion, HSL cells have immature properties and the potential to differentiate into mature cells. Not only the extracellular matrices but also soluble factors, which are produced by hepatic stellate cells, induce this maturation, demonstrating the importance of the hepatic environment for hepatocyte differentiation.  (日)    [継承]
キーワード (推奨): 1. (英) Albumins (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5. (英) Coculture Techniques (日) (読) [継承]
6. (英) Epithelial Cells (日) (読) [継承]
7. (英) Hepatocytes (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) Liver (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Microscopy, Fluorescence (日) (読) [継承]
12. (英) Microscopy, Phase-Contrast (日) (読) [継承]
13. (英) Phenotype (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Rats, Sprague-Dawley (日) (読) [継承]
16. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 293 [継承]
(必須): 5 [継承]
(必須): 1420 1425 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 5月 24日 (平成 14年 5月 24日) [継承]
URL (任意):
DOI (任意): 10.1016/S0006-291X(02)00406-0    (→Scopusで検索) [継承]
PMID (任意): 12054673    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-18444419136 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, Akita University School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirokazu Nagai, Kunihiko Terada, Go Watanabe, Yasuharu Ueno, Namiko Aiba, Tomomi Shibuya, Masami Kawagoe, Takashi Kameda, Mitsuru Sato, Haruki Senoo and Toshihiro Sugiyama : Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cells., Biochemical and Biophysical Research Communications, Vol.293, No.5, 1420-1425, 2002.
欧文冊子 ● Hirokazu Nagai, Kunihiko Terada, Go Watanabe, Yasuharu Ueno, Namiko Aiba, Tomomi Shibuya, Masami Kawagoe, Takashi Kameda, Mitsuru Sato, Haruki Senoo and Toshihiro Sugiyama : Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cells., Biochemical and Biophysical Research Communications, Vol.293, No.5, 1420-1425, 2002.

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