| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 島袋 充生
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Higa Satoshi (日) (読)
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| 3. | (英) Shinzato Tatsushi (日) (読)
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| 4. | (英) Nagamine Fumio (日) (読)
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| 5. | (英) Komiya Ichiro (日) (読)
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| 6. | (英) Takasu Nobuyuki (日) (読)
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| ○題名 (必須): | □ | (英) Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats. (日)
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| ○要約 (任意): | □ | (英) Troglitazone, a new oral antidiabetic agent, shows hypoglycemic effects in insulin-resistant animal models and humans. This study was conducted to evaluate the effects of troglitazone on the heart of diabetic animals. Streptozotocin (STZ)-induced diabetic rats and age-matched controls were treated with troglitazone as a 0.2% food admixture for 6 weeks. Basal and postischemic cardiac functions at 14 weeks of age were then examined in isolated working heart. Troglitazone treatment did not attenuate the insulinopenia and hyperglycemia of diabetic rats, but it partially improved the hypertriglyceridemia. Troglitazone treatment partially restored the basal heart rate and cardiac work of diabetic rats to nearly control values. Troglitazone also improved the postischemic functional deficits of diabetic rats: heart rate (untreated 61% of baseline at 30-minute reperfusion v treated 92%, P < .001), left ventricular (LV) developed pressure (54% v 94%, P < .001), peak positive ([LV + dP/dt] 54% v 93%, P < .001) and negative ([LV -dP/dt] 53% v 94%, P < .001) first derivative of LV, and cardiac work (44% v 98%, P < .001). Diabetic animals showed ultrastructural damage including disarray of sarcomere, disorganization of mitochondrial matrix, cytoplasmic vacuolization, and invagination of nuclear membrane; these were partially normalized by troglitazone treatment. Our results suggest that troglitazone treatment has a cardiprotective effect on the basal and postischemic cardiac function of STZ-induced diabetic rats. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blood Glucose (日) (読)
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| 3. | (英) Body Weight (日) (読)
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| 4. | コレステロール (cholesterol)
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| 5. | (英) Chromans (日) (読)
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| 6. | (英) Diabetes Mellitus, Experimental (日) (読)
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| 7. | 心臓 (heart)
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| 8. | (英) Heart Function Tests (日) (読)
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| 9. | (英) Hypoglycemic Agents (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Microscopy, Electron (日) (読)
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| 12. | 心筋虚血 (myocardial ischemia)
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| 13. | 心筋 (myocardium)
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| 14. | (英) Organ Size (日) (読)
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| 15. | (英) Rats (日) (読)
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| 16. | (英) Rats, Sprague-Dawley (日) (読)
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| 17. | (英) Thiazoles (日) (読)
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| 18. | (英) Thiazolidinediones (日) (読)
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| 19. | (英) Triglycerides (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Metabolism: Clinical and Experimental ([Elsevier])
(pISSN: 0026-0495, eISSN: 1532-8600)
| ○ISSN (任意): | □ | 0026-0495
ISSN: 0026-0495
(pISSN: 0026-0495, eISSN: 1532-8600) Title: Metabolism: clinical and experimentalTitle(ISO): MetabolismPublisher: W.B. Saunders (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 45
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 1168 1173
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1996年 9月 初日 (平成 8年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S0026-0495(96)90018-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 8781306 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0029774572
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| ○備考 (任意): | 1. | (英) Affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of The Ryukyus, Okinawa, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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