『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.島袋 充生
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Shinzato Tatsushi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Higa Satoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nagamine Fumio (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Murakami Keiji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Takasu Nobuyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Impaired mechanical response to calcium of diabetic rat hearts: reversal by nifedipine treatment.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Streptozotocin-induced diabetic and age-matched control rats were treated with 0.03% nifedipine-containing chow for 6 weeks, and mechanical response to Ca2+ was studied using isolated working hearts. At 14 weeks of age, 7 weeks after a streptozotocin injection, diabetic rats had a lower body weight and heart weight than controls, and an increase in heart weight-to-body weight ratio. Nifedipine treatment did not alter these parameters of controls, but decreased the heart weight and heart weight-to-body weight ratio of diabetic rats without affecting the body weight. In diabetic rats, systolic blood pressure was decreased compared to controls (124 +/- 5 vs. 137 +/- 6 mm Hg, p < 0.01), and reduced more by nifedipine treatment (111 +/- 4 mm Hg, p < 0.01). In control rats, LV developed pressure, LV +/- dP/dt, and cardiac work were unchanged regardless of the increment in preload at 1.25, 1.88, and 2.50 mM Ca2+. However, the responses of diabetic rats were decreased with an increment in preload at 2.5 mM Ca2+. Nifedipine treatment produced a partial recovery of all four parameters at 2.5 mM Ca2+ in diabetic rats. The myocardial Ca2+ content and sarcolemmal lipid peroxidation were similar in hearts from control and diabetic rats at all Ca2+ concentrations and nifedipine treatment did not affect these values. Results suggest that chronic nifedipine treatment improve the contractility of diabetic rat hearts under high Ca2+ conditions.  (日)    [継承]
キーワード (推奨): 1.分散分析 (analysis of variance) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blood Glucose (日) (読) [継承]
4.血圧 (blood pressure) [継承]
5. (英) Body Weight (日) (読) [継承]
6.カルシウム (calcium) [継承]
7. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
8.心臓 (heart) [継承]
9. (英) Heart Rate (日) (読) [継承]
10. (英) Hemoglobin A, Glycosylated (日) (読) [継承]
11.インスリン (insulin) [継承]
12.脂質過酸化 (lipid peroxidation) [継承]
13. (英) Male (日) (読) [継承]
14.心筋 (myocardium) [継承]
15. (英) Nifedipine (日) (読) [継承]
16. (英) Organ Size (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Sprague-Dawley (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cardiovascular Pharmacology ([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)

ISSN (任意): 0160-2446
ISSN: 0160-2446 (pISSN: 0160-2446, eISSN: 1533-4023)
Title: Journal of cardiovascular pharmacology
Title(ISO): J Cardiovasc Pharmacol
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 26 [継承]
(必須): 3 [継承]
(必須): 495 502 [継承]
都市 (任意):
年月日 (必須): 西暦 1995年 9月 初日 (平成 7年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00005344-199509000-00022    (→Scopusで検索) [継承]
PMID (任意): 8583794    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0029145963 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa.  (日)    [継承]
2.(英) PublicationType: Comparative Study  (日)    [継承]
3.(英) PublicationType: In Vitro  (日)    [継承]
4.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Michio Shimabukuro, Tatsushi Shinzato, Satoshi Higa, Fumio Nagamine, Keiji Murakami and Nobuyuki Takasu : Impaired mechanical response to calcium of diabetic rat hearts: reversal by nifedipine treatment., Journal of Cardiovascular Pharmacology, Vol.26, No.3, 495-502, 1995.
欧文冊子 ● Michio Shimabukuro, Tatsushi Shinzato, Satoshi Higa, Fumio Nagamine, Keiji Murakami and Nobuyuki Takasu : Impaired mechanical response to calcium of diabetic rat hearts: reversal by nifedipine treatment., Journal of Cardiovascular Pharmacology, Vol.26, No.3, 495-502, 1995.

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