| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 島袋 充生
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Shinzato Tatsushi (日) (読)
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| ○学籍番号 (推奨): |
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| 3. | (英) Higa Satoshi (日) (読)
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| 4. | (英) Nagamine Fumio (日) (読)
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| 5. | (英) Murakami Keiji (日) (読)
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| 6. | (英) Takasu Nobuyuki (日) (読)
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| ○題名 (必須): | □ | (英) Impaired mechanical response to calcium of diabetic rat hearts: reversal by nifedipine treatment. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Streptozotocin-induced diabetic and age-matched control rats were treated with 0.03% nifedipine-containing chow for 6 weeks, and mechanical response to Ca2+ was studied using isolated working hearts. At 14 weeks of age, 7 weeks after a streptozotocin injection, diabetic rats had a lower body weight and heart weight than controls, and an increase in heart weight-to-body weight ratio. Nifedipine treatment did not alter these parameters of controls, but decreased the heart weight and heart weight-to-body weight ratio of diabetic rats without affecting the body weight. In diabetic rats, systolic blood pressure was decreased compared to controls (124 +/- 5 vs. 137 +/- 6 mm Hg, p < 0.01), and reduced more by nifedipine treatment (111 +/- 4 mm Hg, p < 0.01). In control rats, LV developed pressure, LV +/- dP/dt, and cardiac work were unchanged regardless of the increment in preload at 1.25, 1.88, and 2.50 mM Ca2+. However, the responses of diabetic rats were decreased with an increment in preload at 2.5 mM Ca2+. Nifedipine treatment produced a partial recovery of all four parameters at 2.5 mM Ca2+ in diabetic rats. The myocardial Ca2+ content and sarcolemmal lipid peroxidation were similar in hearts from control and diabetic rats at all Ca2+ concentrations and nifedipine treatment did not affect these values. Results suggest that chronic nifedipine treatment improve the contractility of diabetic rat hearts under high Ca2+ conditions. (日)
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| ○キーワード (推奨): | 1. | 分散分析 (analysis of variance)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Blood Glucose (日) (読)
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| 4. | 血圧 (blood pressure)
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| 5. | (英) Body Weight (日) (読)
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| 6. | カルシウム (calcium)
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| 7. | (英) Diabetes Mellitus, Experimental (日) (読)
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| 8. | 心臓 (heart)
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| 9. | (英) Heart Rate (日) (読)
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| 10. | (英) Hemoglobin A, Glycosylated (日) (読)
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| 11. | インスリン (insulin)
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| 12. | 脂質過酸化 (lipid peroxidation)
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| 13. | (英) Male (日) (読)
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| 14. | 心筋 (myocardium)
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| 15. | (英) Nifedipine (日) (読)
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| 16. | (英) Organ Size (日) (読)
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| 17. | (英) Rats (日) (読)
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| 18. | (英) Rats, Sprague-Dawley (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Cardiovascular Pharmacology ([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)
| ○ISSN (任意): | □ | 0160-2446
ISSN: 0160-2446
(pISSN: 0160-2446, eISSN: 1533-4023) Title: Journal of cardiovascular pharmacologyTitle(ISO): J Cardiovasc PharmacolPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 26
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 495 502
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1995年 9月 初日 (平成 7年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/00005344-199509000-00022 (→Scopusで検索)
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| ○PMID (任意): | □ | 8583794 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0029145963
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| ○備考 (任意): | 1. | (英) Affiliation: Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa. (日)
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| 2. | (英) PublicationType: Comparative Study (日)
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| 3. | (英) PublicationType: In Vitro (日)
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| 4. | (英) PublicationType: Journal Article (日)
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