| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Oshiro Yoshito (日) (読)
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| 2. | 島袋 充生
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| 3. | (英) Takasu Nobuyuki (日) (読)
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| 4. | (英) Asahi Tomohiro (日) (読)
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| 5. | (英) Komiya Ichiro (日) (読)
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| 6. | (英) Yoshida Hisashi (日) (読)
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| ○題名 (必須): | □ | (英) Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats. (日)
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| ○要約 (任意): | □ | (英) Acute effects of triiodothyronine (T3) on postischemic myocardial stunning and intracellular Ca2+ contents were studied in the isolated working hearts of streptozotocin-induced diabetic rats and age-matched controls. After two weeks of diabetes, serum T3 and T4 levels were decreased to 62.5% and 33.9% of control values. Basal preischemic cardiac performance did not differ between diabetic and control rats. In contrast, during reperfusion after 20-min ischemia, diabetic rats exhibited an impaired recovery of heart rate (at 30-min reperfusion 57.5% of baseline vs. control 88.5%), left ventricular (LV) systolic pressure (44.1% vs. 89.5%), and cardiac work (23.1% vs. 66.0%). When 1 and 100 nM T3 was added before ischemia, heart rate was recovered to 77.2% and 81.8% of baseline, LV systolic pressure to 68.3% and 81.9%, and cardiac work to 50.8% and 59.0%, respectively. Diabetic rat hearts showed a higher Ca2+ content in the basal state and a further increase after reperfusion (4.96+/-1.17 vs. control 3.78+/-0.48 micromol/g, p<0.01). In diabetic hearts, H+ release was decreased after reperfusion (5.24+/-2.21 vs. 8.70+/-1.41 mmol/min/g, p<0.05). T3 administration caused a decrease in the postischemic Ca2+ accumulation (lnM T3 4.66+/-0.41 and 100 nM T3 3.58+/-0.36) and recovered the H+ release (lnM T3 16.2+/-3.9 and 100 nM T3 11.6+/-0.9). T3 did not alter myocardial O2 consumption. Results suggest that diabetic rat hearts are vulnerable to postischemic stunning, and T3 protects the myocardial stunning possibly via inhibiting Ca2+ overload. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | カルシウム (calcium)
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| 3. | (英) Diabetes Mellitus, Experimental (日) (読)
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| 4. | (英) Dose-Response Relationship, Drug (日) (読)
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| 5. | 心臓 (heart)
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| 6. | (英) Hemodynamics (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Myocardial Reperfusion Injury (日) (読)
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| 9. | (英) Myocardial Stunning (日) (読)
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| 10. | 心筋 (myocardium)
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| 11. | 酸素消費 (oxygen consumption)
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| 12. | (英) Perfusion (日) (読)
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| 13. | (英) Random Allocation (日) (読)
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| 14. | (英) Rats (日) (読)
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| 15. | (英) Rats, Sprague-Dawley (日) (読)
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| 16. | (英) Streptozocin (日) (読)
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| 17. | (英) Thyroxine (日) (読)
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| 18. | (英) Triiodothyronine (日) (読)
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| 19. | (英) Ventricular Function, Left (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)
| ○ISSN (任意): | □ | 0024-3205
ISSN: 0024-3205
(pISSN: 0024-3205, eISSN: 1879-0631) Title: Life sciencesTitle(ISO): Life SciPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 69
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| ○号 (必須): | □ | 16
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| ○頁 (必須): | □ | 1907 1918
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 9月 7日 (平成 13年 9月 7日)
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| ○PMID (任意): | □ | 11693271 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. (日)
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| 2. | (英) PublicationType: In Vitro (日)
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| 3. | (英) PublicationType: Journal Article (日)
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