『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=227579)

EID=227579EID:227579, Map:0, LastModified:2018年6月7日(木) 12:01:03, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Oshiro Yoshito (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.島袋 充生
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Takasu Nobuyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Asahi Tomohiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Komiya Ichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yoshida Hisashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Acute effects of triiodothyronine (T3) on postischemic myocardial stunning and intracellular Ca2+ contents were studied in the isolated working hearts of streptozotocin-induced diabetic rats and age-matched controls. After two weeks of diabetes, serum T3 and T4 levels were decreased to 62.5% and 33.9% of control values. Basal preischemic cardiac performance did not differ between diabetic and control rats. In contrast, during reperfusion after 20-min ischemia, diabetic rats exhibited an impaired recovery of heart rate (at 30-min reperfusion 57.5% of baseline vs. control 88.5%), left ventricular (LV) systolic pressure (44.1% vs. 89.5%), and cardiac work (23.1% vs. 66.0%). When 1 and 100 nM T3 was added before ischemia, heart rate was recovered to 77.2% and 81.8% of baseline, LV systolic pressure to 68.3% and 81.9%, and cardiac work to 50.8% and 59.0%, respectively. Diabetic rat hearts showed a higher Ca2+ content in the basal state and a further increase after reperfusion (4.96+/-1.17 vs. control 3.78+/-0.48 micromol/g, p<0.01). In diabetic hearts, H+ release was decreased after reperfusion (5.24+/-2.21 vs. 8.70+/-1.41 mmol/min/g, p<0.05). T3 administration caused a decrease in the postischemic Ca2+ accumulation (lnM T3 4.66+/-0.41 and 100 nM T3 3.58+/-0.36) and recovered the H+ release (lnM T3 16.2+/-3.9 and 100 nM T3 11.6+/-0.9). T3 did not alter myocardial O2 consumption. Results suggest that diabetic rat hearts are vulnerable to postischemic stunning, and T3 protects the myocardial stunning possibly via inhibiting Ca2+ overload.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.カルシウム (calcium) [継承]
3. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
4. (英) Dose-Response Relationship, Drug (日) (読) [継承]
5.心臓 (heart) [継承]
6. (英) Hemodynamics (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Myocardial Reperfusion Injury (日) (読) [継承]
9. (英) Myocardial Stunning (日) (読) [継承]
10.心筋 (myocardium) [継承]
11.酸素消費 (oxygen consumption) [継承]
12. (英) Perfusion (日) (読) [継承]
13. (英) Random Allocation (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Rats, Sprague-Dawley (日) (読) [継承]
16. (英) Streptozocin (日) (読) [継承]
17. (英) Thyroxine (日) (読) [継承]
18. (英) Triiodothyronine (日) (読) [継承]
19. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)

ISSN (任意): 0024-3205
ISSN: 0024-3205 (pISSN: 0024-3205, eISSN: 1879-0631)
Title: Life sciences
Title(ISO): Life Sci
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 69 [継承]
(必須): 16 [継承]
(必須): 1907 1918 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 9月 7日 (平成 13年 9月 7日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 11693271    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.  (日)    [継承]
2.(英) PublicationType: In Vitro  (日)    [継承]
3.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoshito Oshiro, Michio Shimabukuro, Nobuyuki Takasu, Tomohiro Asahi, Ichiro Komiya and Hisashi Yoshida : Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats., Life Sciences, Vol.69, No.16, 1907-1918, 2001.
欧文冊子 ● Yoshito Oshiro, Michio Shimabukuro, Nobuyuki Takasu, Tomohiro Asahi, Ichiro Komiya and Hisashi Yoshida : Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats., Life Sciences, Vol.69, No.16, 1907-1918, 2001.

関連情報

Number of session users = 0, LA = 3.05, Max(EID) = 383970, Max(EOID) = 1027128.