『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Asahi Tomohiro (日) (読)
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○学籍番号 (推奨):
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2.島袋 充生
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3. (英) Oshiro Yoshito (日) (読)
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4. (英) Yoshida Hisashi (日) (読)
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5. (英) Takasu Nobuyuki (日) (読)
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○題名 (必須): □(英) Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) We evaluated the effects of hyperthyroidism on cardiac structural changes and postischemic myocardial function, and also studied how an angiotensin-converting enzyme (ACE) inhibitor, cilazapril, can alter these changes. Hyperthyroidism was induced by daily intraperitoneal injection of thyroxine (T4) (600 microg/kg) with or without cilazapril (10 mg/kg per day, orally), and control rats were given by vehicle. After 2 weeks of treatment, T4-treated rats showed increases in blood pressure and heart weight to body weight ratio (HW:BW). Cilazapril decreased blood pressure to control values and reduced HW:BW. In the isolated working heart preparation, T4-treated rats showed a poor postischemic recovery of left ventricular pressure-rate product (14% of baseline at 30 minutes of reperfusion vs. vehicle 85%) and cardiac work (6% vs. 71%). Cilazapril recovered both values to 49% and 43%. Propranolol (500 mg/L in drinking water) decreased blood pressure to the same extent as cilazapril in hyperthyroid rats, but changed neither HW:BW nor the postischemic myocardial dysfunction. Percent recovery of cardiac work was inversely well correlated with HW:BW (R2 = 0.998, p < 0.001). Results indicate that T4-induced cardiac hypertrophy enhances postischemic cardiac dysfunction. Results also indicate renin-angiotensin system (RAS), but not sympathetic nerve activation, is involved in cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.  (日)    [継承]
○キーワード (推奨): 1. (英) Adrenergic beta-Antagonists (日) (読) [継承]
2. (英) Angiotensin-Converting Enzyme Inhibitors (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cardiomegaly (日) (読) [継承]
5. (英) Cell Size (日) (読) [継承]
6. (英) Cilazapril (日) (読) [継承]
7. (英) Coronary Circulation (日) (読) [継承]
8. (英) Hemodynamics (日) (読) [継承]
9. (英) Hyperthyroidism (日) (読) [継承]
10. (英) Hypertrophy, Left Ventricular (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12.心筋虚血 (myocardial ischemia) [継承]
13.心筋 (myocardium) [継承]
14. (英) Organ Size (日) (読) [継承]
15.酸素消費 (oxygen consumption) [継承]
16. (英) Propranolol (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Sprague-Dawley (日) (読) [継承]
19. (英) Triiodothyronine (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Thyroid (American Thyroid Association)
(pISSN: 1050-7256, eISSN: 1557-9077)

○ISSN (任意): □1050-7256
ISSN: 1050-7256 (pISSN: 1050-7256, eISSN: 1557-9077)
Title: Thyroid : official journal of the American Thyroid Association
Title(ISO): Thyroid
Publisher: Mary Ann Liebert Inc.
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □11 [継承]
○号 (必須): □11 [継承]
○頁 (必須): □1009 1015 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2001年 11月 1日 (平成 13年 11月 1日) [継承]
○URL (任意):
○DOI (任意): □10.1089/105072501753271680    (→Scopusで検索) [継承]
○PMID (任意): □11762709    (→Scopusで検索) [継承]
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○Scopus (任意): □2-s2.0-0035185883 [継承]
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○備考 (任意): 1.(英) Affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of The Ryukyus, Nishihara, Okinawa, Japan.  (日)    [継承]
2.(英) PublicationType: Comparative Study  (日)    [継承]
3.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Tomohiro Asahi, Michio Shimabukuro, Yoshito Oshiro, Hisashi Yoshida and Nobuyuki Takasu : Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats., Thyroid, Vol.11, No.11, 1009-1015, 2001.
欧文冊子 ● Tomohiro Asahi, Michio Shimabukuro, Yoshito Oshiro, Hisashi Yoshida and Nobuyuki Takasu : Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats., Thyroid, Vol.11, No.11, 1009-1015, 2001.

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