| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Zhou Y T (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Grayburn P (日) (読)
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| ○学籍番号 (推奨): |
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| 3. | (英) Karim A (日) (読)
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| ○学籍番号 (推奨): |
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| 4. | 島袋 充生
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| ○学籍番号 (推奨): |
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| 5. | (英) Higa M (日) (読)
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| ○学籍番号 (推奨): |
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| 6. | (英) Baetens D (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 7. | (英) Orci L (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | (英) Unger R H (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Lipotoxic heart disease in obese rats: implications for human obesity. (日)
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| ○要約 (任意): | □ | (英) To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was high because of underexpression of fatty acid oxidative enzymes and their transcription factor, peroxisome proliferator-activated receptor-alpha. Levels of ceramide, a mediator of apoptosis, were 2-3 times those of controls and inducible nitric oxide synthase levels were 4 times greater than normal. Myocardial DNA laddering, an index of apoptosis, reached 20 times the normal level. Troglitazone therapy lowered myocardial TG and ceramide and completely prevented DNA laddering and loss of cardiac function. In this paper, we conclude that cardiac dysfunction in obesity is caused by lipoapoptosis and is prevented by reducing cardiac lipids. (日)
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| ○キーワード (推奨): | 1. | (英) Age Factors (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | アポトーシス (apoptosis)
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| 4. | (英) Blood Glucose (日) (読)
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| 5. | (英) Body Weight (日) (読)
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| 6. | (英) Chromans (日) (読)
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| 7. | (英) DNA Fragmentation (日) (読)
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| 8. | (英) Echocardiography (日) (読)
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| 9. | (英) Heart Diseases (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | インスリン (insulin)
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| 12. | (英) Lipid Metabolism (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Microscopy, Electron (日) (読)
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| 15. | 心筋 (myocardium)
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| 16. | 肥満症 (obesity)
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| 17. | (英) Organ Size (日) (読)
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| 18. | (英) RNA, Messenger (日) (読)
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| 19. | (英) Rats (日) (読)
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| 20. | (英) Rats, Zucker (日) (読)
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| 21. | (英) Thiazoles (日) (読)
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| 22. | (英) Thiazolidinediones (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 0027-8424
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 97
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1784 1789
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 2月 15日 (平成 12年 2月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.97.4.1784 (→Scopusで検索)
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| ○PMID (任意): | □ | 10677535 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0034652225
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S. (日)
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| 5. | (英) OtherID: PMC26513 (日)
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